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CETP expression in females increases body metabolism under both cold exposure and thermoneutrality contributing to a leaner phenotype

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Autor(es):
Castelli, Julia Z. ; Raposo, Helena F. ; Navarro, Claudia D. C. ; Lazaro, Carolina M. ; Sartori, Marina R. ; Dalla Costa, Ana Paula ; Nogueira, Pedro A. S. ; Velloso, Licio A. ; Vercesi, Anibal E. ; Oliveira, Helena C. F.
Número total de Autores: 10
Tipo de documento: Artigo Científico
Fonte: FASEB JOURNAL; v. 39, n. 3, p. 13-pg., 2025-02-15.
Resumo

Susceptibility to obesity differs depending on the genetic background and housing temperatures. We have recently reported that CETP expressing female mice are leaner due to increased lipolysis, brown adipose tissue (BAT) activity, and body energy expenditure compared to nontransgenic (NTg) littermates under standard housing temperature (22 degrees C). The aim of this study is to evaluate how CETP expression affects body temperature, composition, and metabolism during cold exposure (4 degrees C) and thermoneutrality (30 degrees C). When submitted to cold, CETP mice maintained rectal temperature, body weight, and food intake similarly to NTg mice along acute or chronic exposure to 4 degrees C. The body oxygen consumption in response to an isoproterenol challenge was 21% higher at 22 degrees C, and 41% higher after 7 days of cold exposure in CETP than in NTg mice. In addition, BAT biopsies from CETP mice showed reduced lipid content and increased basal oxygen consumption rates. Under thermoneutrality (30 degrees C), when BAT activity is inhibited, CETP mice showed higher rectal and tail temperatures, increased food intake, and increased energy expenditure. Lean mass was elevated and fat mass reduced in CETP mice kept at 30 degrees C. In this thermoneutral condition, soleus muscle, but not gastrocnemius or liver of CETP mice, showed increased mitochondrial respiration rates. These data indicate that CETP expression confers a greater capacity of elevating body metabolic rates at both cold exposure, through BAT activity, and at thermoneutrality, through increased muscle metabolism. Thus, the CETP expression levels in females should be considered as a new influence in the contexts of obesity and metabolic disorders propensity. (AU)

Processo FAPESP: 19/13862-7 - Influência da CETP na função endotelial e no infarto do miocárdio: possível relação com função mitocondrial
Beneficiário:Carolina Martins Lazaro
Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
Processo FAPESP: 23/02270-7 - Ligando defeitos no reparo do DNA à ativação da resposta inflamatória via cGAS-STING e defeitos na mitofagia em células mononucleares de humanos com declínio cognitivo
Beneficiário:Claudia Daniele Carvalho Navarro
Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado
Processo FAPESP: 19/02340-0 - Impacto da expressão da proteína de transferência de colesteril éster (CETP) na adiposidade em condição de termoneutralidade e dieta obesogênica: foco no tecido adiposo branco
Beneficiário:Júlia Zago Castelli
Modalidade de apoio: Bolsas no Brasil - Mestrado
Processo FAPESP: 13/07607-8 - CMPO - Centro Multidisciplinar de Pesquisa em Obesidade e Doenças Associadas
Beneficiário:Licio Augusto Velloso
Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs