| Texto completo | |
| Autor(es): |
Bueno, Gabriel de Paula
;
de Oliveira, Luiz Vinicius Santos
;
Lourencon, Giovanna Preterotto
;
Fernandes, Victor Hugo Catricala
;
Bozzini, Leandro Alves
;
Clososki, Giuliano Cesar
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | CHEMISTRYSELECT; v. 10, n. 15, p. 7-pg., 2025-04-01. |
| Resumo | |
4-Aminoquinazolines are an important class of heterocyclic aromatic compounds with extensive applications in pharmaceutical synthesis and materials science. Herein, we present a rapid, cost-effective, and efficient approach for N-(alkyl)arylation of 4-chloroquinazolines using PEG-400 as a green solvent alternative in both microwave and conventional heating reactors. These methodologies demonstrate broad compatibility with various substituted amines, yielding favorable outcomes. The developed approach enabled the synthesis of Verubulin, a promising antineoplastic agent for treating several types of cancer, alongside a novel drug analogue, highlighting its potential utility in sustainable drug synthesis and discovery. (AU) | |
| Processo FAPESP: | 22/05327-7 - Explorando o espaço químico medicinal de aromáticos com ferramentas sintéticas altamente seletivas |
| Beneficiário: | Giuliano Cesar Clososki |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |