Autor(es)

Rattes, Isadora Campos ; da Silva, Kethleen Mesquita ; Gama, Patricia

• Tipo de documento: Artigo Científico
• Fonte: Cell Biology International; v. N/A, p. 13-pg., 2025-04-09.

Resumo

This study investigates the distribution and role of the stem cell marker Troy (Tnfrsf19) in the gastric mucosa of rats during postnatal development and the effects of early weaning. Troy, previously identified as a reserve stem cell marker in adult gastric tissues, is examined across various developmental stages from birth to adulthood. We showed that Troy+ cells are scattered throughout the gastric gland in early postnatal stages, but they become concentrated in the basal portion of the gland as the rats mature. Additionally, early weaning affects Troy expression at its gene and protein levels, altering its distribution in the gastric mucosa. This suggests that early dietary changes may disrupt the organization and function of the secondary stem cell niche in the stomach, potentially impacting gastric gland homeostasis. We also used in silico analysis to compare the molecular functions of Troy+ zymogenic and parietal cells, finding distinct roles in proliferation and secretion. The results underscore the importance of Troy in gastric development and highlight the long-term impact of early weaning on gastric tissue organization and cell proliferation dynamics. (AU)

• Processo FAPESP: 20/05117-7 - Caracterização do comportamento de células proliferativas na mucosa gástrica de ratos: efeitos imediatos e tardios do desmame precoce
• Beneficiário: Patrícia Gama
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/05064-0 - Caracterização do nicho de células-tronco na mucosa gástrica de ratos em desenvolvimento e adultos e o papel do desmame precoce sobre essa população
• Beneficiário: Isadora Campos Rattes
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto