Outpatient Radioiodine Therapy for Thyroid Cancer A Safe Nuclear Medicine Procedure

Autor(es)

Willegaignon, Jose ^[1] ; Sapienza, Marcelo ; Ono, Carla ; Watanabe, Tomoco ; Guimaraes, Maria Ines ; Gutterres, Ricardo ^[2] ; Marechal, Maria Helena ^[2] ; Buchpiguel, Carlos

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med, Hosp Clin, Inst Radiol, Ctr Med Nucl, Sch Med, Dept Radiol, BR-05403010 Sao Paulo - Brazil

^[2] Natl Nucl Energy Commiss CNEN, Inst Radioprotect & Dosimetry, Dept Med Phys, Rio De Janeiro - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CLINICAL NUCLEAR MEDICINE; v. 36, n. 6, p. 440-445, JUN 2011.
• Citações Web of Science: 20

Resumo

Purposes: To evaluate the dosimetric effect of outpatient radioiodine therapy for thyroid cancer in members of a patient's family and their living environment, when using iodine-131 doses reaching 7.4 GBq. The following parameters were thus defined: (a) whole-body radiation doses to caregivers, (b) the production of contaminated solid waste, and (c) radiation potential and surface contamination within patients' living quarters. Methods: In total, 100 patients were treated on an outpatient basis, taking into consideration their acceptable living conditions, interests, and willingness to comply with medical and radiation safety guidelines. Both the caregivers and the radiation dose potentiality inside patients' residences were monitored by using thermoluminescent dosimeters. Surface contamination and contaminated solid wastes were identified and measured with a Geiger-Muller detector. Results: A total of 90 monitored individuals received a mean dose of 0.27 (+/- 0.28) mSv, and the maximum dose registered was 1.6 mSv. The mean value for the potential dose within all living quarters was 0.31(+/- 0.34) mSv, and the mean value per monitored surface was 5.58 Bq/cm(2) for all the 1659 points measured. The overall production of contaminated solid wastes was at a low level, being about 3 times less than the exemption level indicated by the International Atomic Energy Agency. Conclusions: This study indicates that the treatment of thyroid cancer by applying radioiodine activities up to 7.4 GBq, on an outpatient basis, is a safe procedure, especially when supervised by qualified professionals. This alternative therapy should be a topic for careful discussion considering the high potential for reducing costs in healthcare and improving patient acceptance. (AU)

• Processo FAPESP: 08/54179-3 - Implantação do tratamento ambulatorial do carcinoma da tireóide com atividades de 100 e 150 mCi de iodo-131 na rotina clínica hospitalar: projeto piloto
• Beneficiário: Carlos Alberto Buchpiguel
• Modalidade de apoio: Auxílio à Pesquisa - Regular