| Texto completo | |
| Autor(es): |
Palombo, Paola
;
Lira, Clarice Ribeiro
;
Badaro, Sara Emi Matos Mendes Ferreira
;
Teodoro, Lucas
;
Cruz, Fabio Cardoso
;
Galduroz, Jose Carlos Fernandes
;
Leao, Rodrigo Molini
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Neuroscience Letters; v. 856, p. 7-pg., 2025-04-17. |
| Resumo | |
Evidence from the literature suggests that alcohol use disorder (AUD) is closely associated with alterations in neuronal plasticity and the memory system, related to modifications in muscarinic receptors. The present study aimed to investigate the effects of systemic injection of biperiden, a muscarinic cholinergic antagonist, in experimental protocols of progressive ratio, 24-hour binge alcohol consumption, and reinstatement of contextinduced ethanol self-administration. The results demonstrated that biperiden at doses of 5 and 10 mg/kg (i.p.) effectively reduced the animals' motivation for alcohol consumption, as evidenced by decreased responses on the active lever and a reduction in the last ratio achieved in the progressive ratio protocol. Furthermore, these same doses significantly reduced ethanol consumption in the 24-hour binge protocol. Treatment with biperiden at doses of 1, 5, and 10 mg/kg also attenuated alcohol-seeking behavior after re-exposure to the context associated with ethanol self-administration. These findings suggest that biperiden may have therapeutic potential in the treatment of alcohol use disorder, indicating that modulation of the cholinergic system could be a promising avenue for further investigation. (AU) | |
| Processo FAPESP: | 13/24986-2 - Participação de pequenos grupos neurais seletivamente ativados (neuronal ensembles) na reinstalação da autoadministração de etanol induzida pelo ambiente: investigação farmacogenética, optogenética e molecular |
| Beneficiário: | Fabio Cardoso Cruz |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 18/15505-4 - Estudo neurobiológico da recaída ao uso de cocaína e crack: identificação de plasticidades em neuronal ensembles que armazenam memórias relacionadas com a adição de drogas |
| Beneficiário: | Fabio Cardoso Cruz |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores - Fase 2 |
| Processo FAPESP: | 17/26225-0 - Pesquisa translacional: análise farmacogenômica da resposta à dependência ao crack e à cocaína |
| Beneficiário: | Paola Palombo |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |