| Texto completo | |
| Autor(es): |
Leite, Bianca de Arruda
;
Rossato, Bruno
;
Gravato, Carlos
;
Dorta, Daniel Junqueira
;
de Oliveira, Danielle Palma
Número total de Autores: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY; v. 296, p. 10-pg., 2025-10-01. |
| Resumo | |
Fipronil sulfone is a persistent oxidative metabolite of the insecticide fipronil, frequently detected in aquatic systems and known to exert neurotoxic effects on non-target organisms. Despite its environmental relevance, the developmental impacts of fipronil sulfone remain underexplored. In this study, zebrafish embryos and larvae were exposed to environmentally relevant concentrations of fipronil sulfone (12.5-1000 mu g/L) at different developmental stages (24, 48, 72, 120, and 144 hpf). Morphological, behavioral, and biochemical endpoints were assessed. Exposure to concentrations >= 125 mu g/L significantly reduced swim bladder inflation (up to 100 % inhibition at >= 250 mu g/L) and induced spinal curvature in over 60 % of larvae. Survival decreased progressively with increasing concentrations, reaching 100 % mortality at 1000 mu g/L. Larvae exposed to 125 mu g/L also exhibited hyperactivity followed by reduced locomotion, likely due to blocked GABAergic receptors and acetylcholinesterase inhibition. Moreover, oxidative stress was confirmed by increased reactive oxygen species and glutathione S-transferase activity. These findings demonstrate that even low concentrations of fipronil sulfone can compromise neurodevelopment and survival in zebrafish, underscoring the need for its inclusion in environmental monitoring and risk assessment frameworks. (AU) | |
| Processo FAPESP: | 14/50945-4 - INCT 2014: Instituto Nacional de Tecnologias Alternativas para Detecção, Avaliação Toxicológica e Remoção de Micropoluentes e Radioativos |
| Beneficiário: | Maria Valnice Boldrin |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 18/24298-2 - Utilização de estratégia de multi-biomarcadores em zebrafish como plataforma para estimar os efeitos neurocomportamentais induzidos por retardantes de chama |
| Beneficiário: | Danielle Palma de Oliveira |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 14/50945-4 - INCT 2014: Instituto Nacional de Tecnologias Alternativas para Detecção, Avaliação Toxicológica e Remoção de Micropoluentes e Radioativos |
| Beneficiário: | Maria Valnice Boldrin |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |