| Texto completo | |
| Autor(es): |
Reboucas, Laura Oliveira
;
Dourado, Isabela Lima Autran
;
Delechiave, Giovanne
;
Camarena, Denisse Esther Mallaupoma
;
Van Vlierberghe, Sandra
;
Catalani, Luiz Henrique
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Polymer Chemistry; v. 16, n. 25, p. 16-pg., 2025-05-27. |
| Resumo | |
In recent years, significant efforts have been dedicated to developing photo-curable biomaterials for medical applications such as prosthetics, tissue engineering, and drug delivery. Although light-based 3D printing techniques enable the fabrication of resorbable medical devices with tailored properties, the shortage of suitable biodegradable materials still constrains their full potential. This study focused on producing resins based on poly(globalide) diacrylate for vat photo-polymerization 3D printing of biocompatible and biodegradable materials. By incorporating into the formulation unsaturated compounds such as poly(ethylene glycol) diacrylate, 1,10-decanediol diacrylate, N-vinylpyrrolidone, and N-isopropylacrylamide, the gelation kinetics, mechanical properties, and hydrolytic degradation rates were effectively modulated. Additionally, the successful post-functionalization of photo-crosslinked films with N-acetylcysteine through thiol-ene click-like chemistry demonstrates the material's potential for surface modification even after processing (photo-crosslinking). As part of the biological evaluation, the in vitro cytotoxicity of each material was tested according to the ISO 10993-5 standard. Finally, the suitability of one of the resins for vat photo-polymerization 3D printing was successfully validated with an LCD-based SLA printer. (AU) | |
| Processo FAPESP: | 18/12602-9 - Síntese e fotorreticulação de poliésteres insaturados derivados de isosorbídeo e pantenol para a impressão 3D de dispositivos médicos reabsorvíveis |
| Beneficiário: | Isabela Lima Autran Dourado |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |
| Processo FAPESP: | 18/13492-2 - Arcabouços sintéticos e naturais aplicados à medicina regenerativa |
| Beneficiário: | Luiz Henrique Catalani |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 22/09992-5 - Técnicas de impressão 3D baseadas em luz aplicadas a polímeros derivados de pantenol |
| Beneficiário: | Isabela Lima Autran Dourado |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Doutorado Direto |
| Processo FAPESP: | 24/08578-6 - Revolucionando o campo da engenharia de tecidos: implantes vivos paciente-específicos na velocidade da luz |
| Beneficiário: | Luiz Henrique Catalani |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |