| Texto completo | |
| Autor(es): |
Nunes, Jessica R.
;
Martins, Tereza S.
;
Lopes, Luciana B.
Número total de Autores: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY; v. 113, p. 14-pg., 2025-11-01. |
| Resumo | |
In this study, we investigated the influence of limonene concentration (1-5 %, w/w) and type of oil phase (isopropyl myristate or tricaprylin) on the physicochemical and irritative properties of nanoemulsions (NEs), as well as their ability to improve the skin penetration and cytotoxicity of the retinoid fenretinide. Our goal was to contribute to the development of nanoformulations for topical administration to the breast skin and prevention of breast cancer recurrence. The NE exhibited diameter below 200 nm (PDI <0.2), negative zeta potential (-9 to -11 mV), and did not cause vascular damage in the choriollantoic membrane of eggs regardless of limonene concentration and oil phase type. However, only NEs with isopropyl myristate as the oil phase and 1-2.5 % limonene remained stable for 6 months, and incorporation protected limonene from evaporation. Fenretinide skin penetration increased with time and limonene concentration; NEs containing 2.5 % limonene provided the highest (5.8-fold) fenretinide penetration into viable skin layers at 12 h. Incorporation in the limonene-containing NEs increased fenretinide cytotoxicity against MCF-7 cells, and reduced the migration of MCF-7 and MDA-MB-231 cells (1.5-2-fold) at non-cytotoxic concentrations, supporting the NE potential applicability for topical preventive and adjuvant therapy of breast cancer. (AU) | |
| Processo FAPESP: | 19/08582-5 - EMU concedido no processo 17/17844-8:Analisador térmico - TG/DTA modelo sta 2500 TG/DTA TEMP. ambiente a 1100 °c |
| Beneficiário: | Tereza da Silva Martins |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa Equipamentos Multiusuários |
| Processo FAPESP: | 18/13877-1 - Nanocarreadores para a quimioprevenção e tratamento localizado de tumores de mama |
| Beneficiário: | Luciana Biagini Lopes |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores - Fase 2 |
| Processo FAPESP: | 24/03868-6 - Estratégias de quimioprevenção para o câncer de mama: estudo de nanocarreadores contendo fenretinida para emprego na terapia tópica-transdérmica |
| Beneficiário: | Jessica Ribeiro Nunes |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 21/06755-0 - Avaliação de nanoemulsões para administração tópico-transdérmica de fenretinida como estratégia de quimioprevenção |
| Beneficiário: | Jessica Ribeiro Nunes |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 14/50928-2 - INCT 2014: Nanotecnologia Farmacêutica: uma abordagem transdisciplinar |
| Beneficiário: | Maria Vitória Lopes Badra Bentley |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |