Autor(es)

Gomes-Junior, Paulo Cardoso ; Augusto, Karen Kenlderi de Lima ; Longatto, Gustavo Patelli ; Goncalves, Renan de Oliveira ; Cavalheiro, Eder Tadeu Gomes ; Fatibello-Filho, Orlando ; Piccin, Evandro

• Tipo de documento: Artigo Científico
• Fonte: Talanta; v. 298, p. 12-pg., 2026-02-01.

Resumo

Deep eutectic solvents (DES) are emerging as eco-friendly alternatives to hazardous organic solvents due to their biodegradability, low volatility, and thermal stability. This study presents the use of a DES composed of choline chloride (ChCl) and diethanolamine (DEA) as medium to synthesize silver nanoparticles (AgNPs). The resulting nanoparticles were subsequently utilized in the fabrication of a composite electrochemical sensor. Firstly, for the DES, the eutectic point was determined using differential scanning calorimetry (DSC). Characterizations using FTIR and NMR spectroscopy provided insights into precursor interactions, while physicochemical properties such as water content, conductivity, and viscosity were also evaluated. The synthesis of AgNPs in the DES medium was possible without using a conventional reducing agent and at a temperature below 100 degrees C. Transmission electron microscopy (TEM), energy dispersive spectroscopy (EDS), selected area electron diffraction (SAED), and X-ray diffraction (XRD) revealed AgNPs with varied shapes and polycrystalline nature with cubic structures. These AgNPs were then used to construct a composite sensor with carbon black (CB) for detecting famotidine (FMT). The sensor exhibited enhanced performance, especially due to AgNPs-DES, which allowed linear response for FMT in the range 0.5-260 mu mol L-1, with a limit of detection of 90 nmol L-1. Excellent performances were verified for repeatability, anti-interferences features, and to determine FMT in pharmaceutical and biological fluid samples. Key metrics such as the diffusion coefficient ((1.1 +/- 0.5) x 10-4 cm2 s-1) and catalytic constant ((1.0 +/- 0.1) x 103 mol-1 L s-1) were significantly improved with the addition of AgNPs in the sensor. (AU)

• Processo FAPESP: 24/04116-8 - Emprego de solventes eutéticos profundos em procedimentos espectrofotométricos e eletroanalíticos sustentáveis
• Beneficiário: Orlando Fatibello Filho
• Modalidade de apoio: Auxílio à Pesquisa - Regular