Autor(es)

Parra, Joao Paulo Ruiz Lucio de Lima ; Martins, Murillo Longo ; Pedrosa, Valber de Albuquerque ; Andrade, Amanda Fantini de Camargo ; Gomes, Anderson Moreira ; Feltran, Georgia da Silva ; Comparetti, Edson Jose ; Zucolotto, Valtencir ; Zambuzzi, Willian Fernando

• Tipo de documento: Artigo Científico
• Fonte: COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS; v. 727, p. 12-pg., 2025-12-20.

Resumo

Bone research benefits from recent developments of advanced composites combining polymers and solid nanoparticles. Here, we investigate composites comprising chitosan, hydroxyapatite, and carbon nanotubes, providing insights into the polymer-nanoparticle interactions and the relationships of these compounds with water. These results were combined with assays performed with pre-osteoblastic cells. We observe that chitosan's amine moieties hardly participate in the polymer/nanoparticles interactions, and the nanotubes barely contribute to the formation of interfacial water populations. Conversely, hydroxyapatite directly affects the behavior of interfacial and bulk-like water within the composite due to the hydrophilic character of these particles and their gradual degradation within the chitosan network. In the biological assays, the chitosan/hydroxyapatite composite induces a fast cellular response followed by a negative effect, likely because of a meaningful release of ions to the media. However, adding nanotubes to the formulation mitigates this effect and enables a more sustainable, positive impact on the cells. (AU)

• Processo FAPESP: 24/00063-7 - Dispositivo vestível para monitoramento contínuo e em tempo real de biomarcadores
• Beneficiário: Valber de Albuquerque Pedrosa
• Modalidade de apoio: Bolsas no Exterior - Pesquisa
• Processo FAPESP: 19/09735-0 - BONEInk: síntese e caracterização de quitosana reticulada com nanotubos de carbono modificados com peptídeos RGD e cristais de HA para potencial aplicação de bioimpressão de tecido ósseo
• Beneficiário: João Paulo Ruiz Lucio de Lima Parra
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 19/13411-5 - Desenvolvimento de dispositivo microfluídico para biopsia líquida de células tumorais circulantes
• Beneficiário: Valber de Albuquerque Pedrosa
• Modalidade de apoio: Auxílio à Pesquisa - Regular