Autor(es)

Proios, Dimitrios ; Bornet, Alban ; Yazdani, Anthony ; Rodrigues, Jose F., Jr. ; Teodoro, Douglas

• Tipo de documento: Artigo Científico
• Fonte: 2025 IEEE 38TH INTERNATIONAL SYMPOSIUM ON COMPUTER-BASED MEDICAL SYSTEMS, CBMS; v. N/A, p. 6-pg., 2025-01-01.

Resumo

Patient stratification-identifying clinically meaningful subgroups-is essential for advancing personalized medicine through improved diagnostics and treatment strategies. Electronic health records (EHRs), particularly those from intensive care units (ICUs), contain rich temporal clinical data that can be leveraged for this purpose. In this work, we introduce ICU-TSB (Temporal Stratification Benchmark), the first comprehensive benchmark for evaluating patient stratification based on temporal patient representation learning using three publicly available ICU EHR datasets. A key contribution of our benchmark is a novel hierarchical evaluation framework utilizing disease taxonomies to measure the alignment of discovered clusters with clinically validated disease groupings. In our experiments with ICU-TSB, we compared statistical methods and several recurrent neural networks, including LSTM and GRU, for their ability to generate effective patient representations for subsequent clustering of patient trajectories. Our results demonstrate that temporal representation learning can rediscover clinically meaningful patient cohorts; nevertheless, it remains a challenging task, with v-measuring varying from up to 0.46 at the top level of the taxonomy to up to 0.40 at the lowest level. To further enhance the practical utility of our findings, we also evaluate multiple strategies for assigning interpretable labels to the identified clusters. The experiments and benchmark are fully reproducible and available at https://github.com/ds4dh/CBMS2025stratification. (AU)

• Processo FAPESP: 24/04761-0 - Inteligência Artificial para Melhoria dos Resultados em Doenças Infecciosas em Receptores de Transplante Renal (AIIDKIT)
• Beneficiário: José Fernando Rodrigues Júnior
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 19/07665-4 - Centro de Inteligência Artificial
• Beneficiário: Fabio Gagliardi Cozman
• Modalidade de apoio: Auxílio à Pesquisa - Programa eScience e Data Science - Centros de Pesquisa Aplicada