| Texto completo | |
| Autor(es): |
Ferreira, Iara Vieira
;
de Lima-Souza, Reydson Alcides
;
Kimura, Talita de Carvalho
;
Tincani, Alfio Jose
;
Cattan, Marcelo Elias Schempf
;
Antolini-Tavares, Arthur
;
Altemani, Albina
;
Mariano, Fernanda Viviane
Número total de Autores: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ORAL DISEASES; v. N/A, p. 12-pg., 2025-09-30. |
| Resumo | |
Objective This study aimed to systematically review primary sarcomas in the oral and maxillofacial region, focusing on patient demographics and sarcoma-specific characteristics, including clinical presentation, histopathology, treatment approaches, outcomes, and survival rates. Materials and Methods A systematic review was conducted in accordance with PRISMA 2020 guidelines and based on the PECOS framework, including observational studies on primary oral and maxillofacial sarcomas. An electronic search in five databases identified eligible studies, and outcomes were analyzed via Kaplan-Meier and Cox regression. Results The review included 35 studies comprising 687 cases of sarcomas in the oral and maxillofacial region. The mean patient age was 35.26 years, with a slight male predominance. Lesions predominantly involved the mandible, with osteosarcoma being the most common histological subtype. Multimodal treatment was most frequent. Of 616 patients with survival data, 58.1% were alive at analysis. The overall 5-year survival and disease-free survival rates were 54.3% and 60.4%, respectively. Factors such as age, histological type, T classification, stage grouping, surgical margins, local recurrence, and distant metastases significantly influenced survival (p < 0.05). Conclusion This study provides a comprehensive review of oral and maxillofacial sarcomas, offering data to understand the clinicopathological characteristics of these lesions, helping to improve their diagnosis and management. (AU) | |
| Processo FAPESP: | 20/08431-4 - Análise do perfil metabolômico na transformação maligna do adenoma pleomórfico |
| Beneficiário: | Reydson Alcides de Lima Souza |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 24/14439-9 - Desvendando os mecanismos etiopatogênicos do carcinoma de células acinares e do carcinoma secretor de glândula salivar: um estudo baseado em análise multiômica integrativa |
| Beneficiário: | Reydson Alcides de Lima Souza |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 23/13091-6 - AVALIAÇÃO DA EXPRESSÃO DE miRNAs E POTENCIAIS ALVOS NA TRANSFORMAÇÃO MALIGNA DO ADENOMA PLEOMÓRFICO |
| Beneficiário: | Talita de Carvalho Kimura |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |