| Texto completo | |
| Autor(es): |
Culha, Merve
;
Lira, Fabio S.
;
Rosa-Neto, Jose C.
Número total de Autores: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | FRONTIERS IN ONCOLOGY; v. 15, p. 8-pg., 2025-08-13. |
| Resumo | |
Exercise decreases cancer risk, prevents recurrence and enhances treatment efficacy, however its exact mechanisms remain unclear. This review aims to (i) summarize the miRNAs released during aerobic exercise and explore the factors influencing their levels; (ii) discuss the miRNAs associated with cancer and exercise. Exercise alters circulated-miRNA levels. Some of them show benefits on tumor and anti-tumoral immune cells (miRNA-1, miRNA-133, miRNA-206, miRNA-208, miRNA-486, miRNA-499) and others exert adverse effects (miRNA-21, miRNA-221). Mechanisms of exercise effects on cancer are complex due to some exercise- induced miRNAs exert advantageous, others not, individual characteristics and exercise features influencing the miRNAs levels. Further studies are needed to elaborate the exercise features on immune response and tumor cell functions, including miRNA production. (AU) | |
| Processo FAPESP: | 22/06073-9 - Efeito dos clock genes sobre a regulação do imunometabolismo e diferenciação de monócitos/macrófagos durante a imunossenescência: o papel do treinamento físico ao longo da vida |
| Beneficiário: | José Cesar Rosa Neto |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |