Autor(es)

Sasaki, Alan Eidi ; Benites, Nikollas Moreira ; Rodrigues, Beatriz ; Juliano Jr, Ricardo Amaral ; Boaretto, Natalia ; de Oliveira, Mario Henrique Duarte ; Leao, Ricardo Mauricio

• Tipo de documento: Artigo Científico
• Fonte: HEARING RESEARCH; v. 466, p. 9-pg., 2025-08-14.

Resumo

Rodent auditory brainstem neurons undergo substantial electrophysiological maturation during the postnatal period, spanning both pre-and post-hearing phases. These developmental adaptations support high-frequency, temporally precise neurotransmission and action potential firing. In the dorsal cochlear nucleus (DCN), fusiform neurons exhibit marked postnatal changes after the onset of hearing (postnatal day 14, P14), including refined action potential firing and the emergence of spontaneous activity. However, whether these changes are driven by acoustic input following ear canal opening remains unclear. To address this, we used a model of early hearing deprivation (EHD) in mice by inserting silicon earplugs at P14, elevating auditory thresholds by 30-40 dB, and assessed fusiform neuron electrophysiology 5-7 days later. Contrary to our hypothesis, neurons from EHD mice displayed properties similar to those of sham-treated animals. In contrast, both groups differed significantly from untreated controls, suggesting a potential influence of isoflurane anesthesia. Our findings indicate that the maturation of DCN fusiform neurons occurs independently of normal acoustic stimulation, suggesting that an intrinsic developmental program might be more relevant than experience-driven refinement. (AU)

• Processo FAPESP: 19/13458-1 - Alterações durante o desenvolvimento das correntes iônicas e neurotransmissão de neurônios ligados a processamento auditivo: efeitos do ambiente acústico
• Beneficiário: Ricardo Mauricio Xavier Leão
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 22/14196-3 - Canais de potássio sensíveis ao ATP no controle da excitabilidade neuronal
• Beneficiário: Ricardo Mauricio Xavier Leão
• Modalidade de apoio: Auxílio à Pesquisa - Regular