| Texto completo | |
| Autor(es): Mostrar menos - |
da Silva, Francisco H. S.
;
de Jesus, Leonardo S.
;
Recchia, Michael J. J.
;
de Morais, Kleyton J. G.
;
Goncalves, Camila M. C.
;
Soares, Sandra R. C.
;
Domingos, Helori V.
;
Cavanagh, Hannah
;
Gueiros-Filho, Frederico J.
;
Lindoso, Jose A. L.
;
Costa-Lotufo, Leticia V.
;
Linington, Roger G.
;
Berlinck, Roberto G. S.
;
Crnkovic, Camila M.
Número total de Autores: 14
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ACS OMEGA; v. N/A, p. 15-pg., 2025-10-24. |
| Resumo | |
Investigations on cyanobacterial secondary metabolites in Brazil have been scarce, despite the country's significant biodiversity. Herein, we report the results of a screening of cyanobacterial cultures using both bioassays and untargeted metabolomics. Nineteen cyanobacterial strains collected at various locations in Brazil were cultured. Cultures were extracted and prefractionated. Fractions were evaluated for antibacterial, cytotoxic, and antileishmanial activities. The same fractions were analyzed by UHPLC-HRMS-MS/MS. Results from bioassays and LC-MS were integrated using metabolomics tools such as NP Analyst and GNPS Molecular Networking, allowing for feature prioritization. Cyanobacteria belonging to genera Calothrix and Phormidium presented high-priority molecular features associated with observed biological activities, indicating that such strains are producers of potentially novel and bioactive metabolites. (AU) | |
| Processo FAPESP: | 20/07710-7 - Prospecção biotecnológica de produtos naturais a partir de cianobactérias |
| Beneficiário: | Camila Manoel Crnkovic |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa BIOTA - Regular |
| Processo FAPESP: | 19/17721-9 - A função da Química na adaptação de holobiontes |
| Beneficiário: | Roberto Gomes de Souza Berlinck |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 22/02872-4 - Estratégias integradas para a descoberta de produtos naturais de cianobactérias brasileiras |
| Beneficiário: | Camila Manoel Crnkovic |
| Modalidade de apoio: | Auxílio à Pesquisa - Projeto Inicial |