| Texto completo | |
| Autor(es): Mostrar menos - |
da Silva-Santos, Yasmin
;
Pagni, Roberta Liberato
;
Gamon, Thais Helena Martins
;
de Azevedo, Marcela Santiago Pacheco
;
Darido, Maria Laura Goussain
;
de Oliveira, Danielle Bruna Leal
;
Durigon, Edson Luiz
;
Luvizotto, Maria Cecilia Rui
;
Ackerman, Hans Christian
;
Marinho, Claudio Romero Farias
;
Carvalho, Leonardo Jose de Moura
;
Epiphanio, Sabrina
Número total de Autores: 12
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| Tipo de documento: | Artigo Científico |
| Fonte: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 26, n. 16, p. 18-pg., 2025-08-08. |
| Resumo | |
The regulation of angiotensin-converting enzyme 2 (ACE2) expression by medications such as ACE inhibitors (ACEis) and angiotensin receptor blockers (ARBs) has raised critical questions regarding their potential benefits and risks during COVID-19. ACE2, a regulator of blood pressure through the renin-angiotensin system (RAS), is the primary receptor for SARS-CoV-2. ACEis and ARBs can modulate ACE2 expression, potentially exacerbating viral load. However, the risks of higher viral load could be mitigated by favorable anti-inflammatory responses associated with ACEi and ARB use, highlighting the complexity of their impact on viral replication and disease outcomes. This study investigates the effects of sustained Losartan monotherapy (ARB) and combination Losartan + Lisinopril (ARB + ACEi) on viral replication, inflammation, lung function, and clinical measures of disease severity in a murine model of severe COVID-19 involving humanized ACE2 transgenic mice infected with SARS-CoV-2 Wuhan strain. Both ARB and ARB + ACEi treatments led to increased ACE2 expression in the lungs and higher viral load post-infection. Despite this, the ARB + ACEi combination improved clinical scores, reduced weight loss and inflammatory cytokine levels, and preserved lung function, though it did not improve survival. Overall, the results of these controlled experiments provide insight into the complex dynamics of ACEi and ARB use in COVID-19; while these drugs induce expression of the ACE2 receptor and increase viral load, they provide compensatory modulation of the inflammatory response that appears to diminish severity of the infection. (AU) | |
| Processo FAPESP: | 22/13150-0 - Inflamação induzida por Malária: uma nova via para doenças cardiovasculares |
| Beneficiário: | Cláudio Romero Farias Marinho |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 23/05478-8 - A regulação da Septina 9 na Síndrome do Desconforto Respiratório Agudo associada à Malária: da citoadesão ao aumento da permeabilidade vascular |
| Beneficiário: | Sabrina Epiphanio |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |