| Texto completo | |
| Autor(es): |
Dias, Andre Rodrigues Lourenco
;
Antonio, Ednei Luiz
;
de Oliveira, Helenita Antonia
;
Teixeira, Ighor Luiz Azevedo
;
Seibt, Larissa Emilia
;
Serra, Andrey Jorge
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | BIOMEDICINES; v. 13, n. 9, p. 18-pg., 2025-09-10. |
| Resumo | |
Background: There is no information on how the dose of exercise training prior to myocardial infarction (MI) affects cardioprotection. Objective: This study aimed to evaluate the cardioprotective role of different volumes of exercise training prior to MI. Methods: Wistar female rats were allocated to one of the following groups: SHAM (not trained and undergoing simulated MI surgery), NT+MI (untrained and undergoing MI surgery), T60+MI (trained 60 min per session and undergoing MI surgery), T90+MI (trained 90 min per session and undergoing MI surgery), and T180+MI (trained 180 min per session and undergoing MI surgery). The training protocol was performed in a swimming pool for eight weeks. On the seventh day after MI, the animals underwent left ventricular (LV) structural and functional evaluation and were euthanized for molecular analyses. Results: Exercise training groups had greater VO2peak and LV mass than did the SHAM group. The MI size did not differ statistically among the experimental groups. Compared with the SHAM group, all the MI groups presented a lower LV shortening fraction. LV systolic pressure was significantly lower in the T60+MI group than in the SHAM and T180+MI groups. The +dP/dt of the LV was significantly lower in the NT+MI, T60+MI, and T90+MI groups than in the SHAM group. We did not find significant changes in the inflammatory mediators and oxidative stress markers as well as proteins involved in calcium handling. Conclusions: Exercise training prior to MI enhanced cardiorespiratory fitness and induced LV hypertrophy, however, regardless of volume, was unable to counteract the detrimental effects of MI. (AU) | |
| Processo FAPESP: | 21/05084-4 - Transplante de células-tronco mesenquimais pode reduzir arritmias ventroculares induzidas em ratas com infarto do miocárdio? |
| Beneficiário: | Andrey Jorge Serra |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 23/17028-7 - EMU: ECOCARDIOGRAFIA APLICADA A MODELOS EXPERIMENTAIS DE DOENÇA CARDIOVASCULAR Aquisição de um ecocardiograma EPIQ CVx 2D SYSTEM (Philips Medical Systems Ltda) para estudo cardiovascular. |
| Beneficiário: | Andrey Jorge Serra |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa Infraestrutura - Pequeno Médio Porte |
| Processo FAPESP: | 15/11028-9 - A modalidade de treinamento físico aeróbio pode determinar a existência de remodelamento cardíaco: identificando peculiaridades estruturais, funcionais e moleculares dos modelos experimentais de natação e corrida |
| Beneficiário: | Andrey Jorge Serra |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 13/20011-7 - Caracterização do remodelamento cardíaco induzido pelo treinamento físico aeróbio de corrida e natação em ratos |
| Beneficiário: | Amanda Yoshizaki dos Santos |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |