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Ali, Sher
;
Franco, Bruna Battaglini
;
Rezende, Vanessa Theodoro
;
Ullah, Sana
;
Wahab, Nida
;
Freire, Lucas Gabriel Dionisio
;
Rosim, Roice Eliana
;
Tonin, Fernando Gustavo
;
Corassin, Carlos Humberto
;
Del Ciampo, Luiz Antonio
;
Ferraz, Ivan Savioli
;
de Oliveira, Carlos Augusto Fernandes
Número total de Autores: 12
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| Tipo de documento: | Artigo Científico |
| Fonte: | Environmental Pollution; v. 385, p. 12-pg., 2025-09-26. |
| Resumo | |
This study assessed mycotoxin exposure of preschoolers (3-6 years, n = 26), schoolers (7-10 years, n = 29), and adolescents (11-17 years, n = 49) from S & atilde;o Paulo, Brazil, by analyzing mycotoxin biomarkers in urine samples. Analyses were performed using ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS), for determination of aflatoxin M-1 (AFM(1)), ochratoxin A (OTA), fumonisins B-1 (FB1) and B-2 (FB2), deoxynivalenol (DON), T-2 and HT-2 toxins, zearalenone (ZEN) and its metabolites alpha- and beta-zearalenol (ZEL). Urinary ZEN and its metabolites (alpha- and beta-ZEL) were the most frequently detected biomarkers, followed by FBs (FB1+FB2), DON, and OTA. Co-exposure to 2-6 mycotoxins was observed in 63 % of samples, most prominently among schoolers (69 %), followed by adolescents (63 %) and preschoolers (61 %). Estimated daily intake (EDI) values were calculated under lower (LB), middle (MB), and upper bound (UB) scenarios. Several 95th percentile UB-EDI values exceeded maximum level (ML) or tolerable daily intake (TDI) limits, particularly for preschoolers regarding exposure to AFM(1) (EDI: 0.786 mu g/kg body weight (bw)/day), FBs (EDI: 5.22 mu g/kg bw/day), OTA (EDI: 0.683 mu g/kg bw/day) and the sum of ZEN, alpha- and beta-ZEL (ZENeq) (0.92 mu g/kg bw/day). Under the UB scenario, hazard quotient (HQ) values > 1 were found for OTA in 100 % of preschoolers (median: 1.71) and schoolers (1.4), and ZENeq in about 77 % of preschoolers (median: 1.14). Margin of exposure (MoE) values for AFM(1) were <10,000 across all age groups, indicating potential carcinogenic concern. These results underscore substantial real-life co-exposure to multiple mycotoxins in children in Brazil, reinforcing the need for age-specific surveillance and risk management strategies. The detection of multiple toxins above safety thresholds highlights the vulnerability of this population and the importance of strengthened food safety policies. (AU) | |
| Processo FAPESP: | 23/05989-2 - Avaliação da co-ocorrência de micotoxinas em alimentos infantis em Pirassununga e Ribeirão Preto/SP |
| Beneficiário: | Sana Ullah |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |
| Processo FAPESP: | 22/01920-5 - EMU concedido no processo 2019/21603-1: sistema de extração em fase sólida (SPE) GX-274 ASPEC, marca Gilson |
| Beneficiário: | Carlos Augusto Fernandes de Oliveira |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa Equipamentos Multiusuários |
| Processo FAPESP: | 22/05066-9 - Avaliação da eficácia de iogurte funcional para diminuir os efeitos tóxicos das aflatoxinas, administradas isoladamente ou em conjunto com fumonisinas na ração, sobre leitões |
| Beneficiário: | Lucas Gabriel Dionisio Freire |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |
| Processo FAPESP: | 22/03952-1 - Avaliação da exposição de crianças às micotoxinas através da dieta em Ribeirão Preto/SP |
| Beneficiário: | Sher Ali |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 19/21603-1 - Abordagens de biomarcadores para avaliar a exposição precoce a múltiplas micotoxinas na dieta |
| Beneficiário: | Carlos Augusto Fernandes de Oliveira |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |