| Texto completo | |
| Autor(es): |
Duraes Pereira, Vinicius Rodrigues
;
Vargas, Geovana Fontes
;
Braga, Taniris Cafiero
;
dos Santos, Juliana Alves
;
Clososki, Giuliano Cesar
;
Nallar, Jaime Alberto Rabi
;
Pinho, Vagner Dantas
;
Amarante, Giovanni Wilson
Número total de Autores: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | EUROPEAN JOURNAL OF ORGANIC CHEMISTRY; v. N/A, p. 6-pg., 2025-10-24. |
| Resumo | |
An optimized gram-scale synthetic route to pyrrolo[2,1-f][1,2,4]triazin-4-amine is reported, affording an overall yield of 85%. Furthermore, regioselective C7-functionalization is achieved via both organometallic and direct strategies, whereas NH2-derivatization proceeds through Buchwald-Hartwig-type coupling, providing derivatives in isolated yields ranging from 8% to >99%. These advancements enhance synthetic accessibility and facilitate efficient structural diversification of this significant N-heterocycle. (AU) | |
| Processo FAPESP: | 22/05327-7 - Explorando o espaço químico medicinal de aromáticos com ferramentas sintéticas altamente seletivas |
| Beneficiário: | Giuliano Cesar Clososki |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |