| Texto completo | |
| Autor(es): |
Palotino-Ferreira, Bruna Maria
;
Rocha, Saulo Vasconcelos
;
Nunes-Silva, Albena
;
Souza-Gomes, Antonio Felipe
;
Rodrigues, Francisco
;
Coelho, Patricia
;
Bachi, Andre Luis Lacerda
;
de Oliveira, Rodrigo Assuncao
;
de Barros, Marcelo Paes
;
Furtado, Guilherme Eustaquio
Número total de Autores: 10
|
| Tipo de documento: | Artigo Científico |
| Fonte: | IMMUNITY & AGEING; v. 22, n. 1, p. 14-pg., 2025-10-30. |
| Resumo | |
BackgroundAmidst the ongoing COVID-19 pandemic, understanding factors that influence vaccine efficacy is crucial, particularly in older adults. Regular physical exercise and/or structured physical activity (SPA) has emerged as a potential modulator of immune responses, enhancing vaccine effectiveness. This systematic review aims to consolidate current evidence on the impact of SPA/exercise on both immune and inflammatory responses to COVID-19 vaccination in adults and older individuals.MethodsMost relevant studies were extracted from indexed databases using health subject terms in English, Portuguese, and Spanish. Studies that examined the impact of regular exercise or SPA on inflammatory and/or immunological responses in relation to COVID-19 immunization were selected. In particular, all chosen studies included individuals who received vaccinations either prior to or following the exercise regimen or SPA, and the main goal was to evaluate these effects on immunological and/or inflammatory reactions induced by vaccination.ResultsAmong the 7 studies included (n = 1149), the effects of regular exercise or PA on vaccine-induced immune responses while concurrently assessing inflammatory markers were examined. The findings suggest that moderate to high-intensity structured physical activity (50-70% of maximum heart rate for aerobic exercise and 60-80% of 1RM for resistance training), performed 3-5 times per week, was able to enhance immune responses to COVID-19 vaccination, particularly by mitigating chronic low-grade inflammation. Acute exercise can transiently boost immunity, whilst engagement in moderate SPA over a period of six months may contribute to sustained improvements in immune function, especially in older adults. However, these findings should be interpreted with caution due to variability in study design, sample characteristics, and potential confounding factors.ConclusionRegular exercise and SPA play a significant role in improving immune/inflammatory responses to COVID-19 vaccination. Older adults, in particular, may benefit from regular SPA and exercise as a strategy to counteract immunosenescence and optimize vaccine efficacy. However, further research is needed to better refine exercise protocols and determine long-term benefits in different populations. (AU) | |
| Processo FAPESP: | 16/04845-3 - INFLUÊNCIA DA INGESTÃO DIÁRIA DO Lactobacillus casei Shirota (LcS) NA RESPOSTA IMUNE SISTÊMICA E DAS VIAS AÉREAS SUPERIORES DE MARATONISTAS AMADORES QUE APRESENTEM MOLÉSTIAS DE VIAS AÉREAS SUPERIORES |
| Beneficiário: | André Luis Lacerda Bachi |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 19/14115-0 - Influência da suplementação de L-glutamina na sarcopenia e resposta imune/inflamatória sistêmica e das vias aéreas de idosos praticantes ou não de um programa regular de exercícios físicos combinados submetidas à vacinação contra o vírus Influenza |
| Beneficiário: | André Luis Lacerda Bachi |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 10/50025-1 - Influência da atividade física na resposta imune sistêmica e da mucosa das vias aéreas superiores de idosos submetidos a vacinação contra doenças respiratórias |
| Beneficiário: | André Luis Lacerda Bachi |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |