| Texto completo | |
| Autor(es): |
Calvano Kuchler, E.
;
Arid, J.
;
Palinkas, M.
;
Ayumi Omori, M.
;
de Lara, R. M.
;
Napolitano Goncalves, L. M.
;
Hallak Regalo, S. C.
;
Paes Torres Mantovani, C.
;
Rezende Vieira, A.
;
Diaz-Serrano, K.
Número total de Autores: 10
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of Clinical Pediatric Dentistry; v. 44, n. 3, p. 5-pg., 2020-01-01. |
| Resumo | |
Objective: Bruxism is a condition defined as a masticatory muscle activity with an unexplored genetic background. The aim of this study was to evaluate the association between genetic polymorphisms in ACTN3 and bruxism. Study design: A total of 151 biological-unrelated children, aged 7-12 years were included in a case control ratio of 1:1.5. The data collection was performed during interview and clinical examination. Saliva samples were collected from all children and 3 genetic polymorphisms in the ACTN3 (rs678397, rs1671064 and rs1815739) were selected for genotyping using real time PCR. Pearson chisquare calculation was used to assess Hardy-Weinberg equilibrium and to evaluate the association between genotypes and alleles frequencies for each genetic polymorphism in the co-dominant and recessive models. An alpha of 5% was used. Results: The genetic polymorphisms rs678397, rs1671064 and rs1815739 were associated with bruxism in the co-dominate model and in the recessive model (p<0.05). Allele distribution was also associated with bruxism for the polymorphisms rs678397 and rs1671064 (p<0.05). Conclusion: The genetic polymorphisms rs678397, rs1671064 and rs1815739 in ACTN3 are associated with bruxism and can contribute to the etiology of this condition in children. (AU) | |
| Processo FAPESP: | 15/06866-5 - Avaliação do papel do estrógeno no desenvolvimento dentofacial |
| Beneficiário: | Erika Calvano Kuchler |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |