| Texto completo | |
| Autor(es): |
Zanin, Lucas L.
;
Porto, Andre L. M.
Número total de Autores: 2
|
| Tipo de documento: | Artigo Científico |
| Fonte: | CHEMISTRYSELECT; v. 5, n. 28, p. 5-pg., 2020-07-31. |
| Resumo | |
An accessible, non-toxic, easy to handle and stock catalyst with high efficiency was developed in this study for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones. Al(2)O(3)was used as a support for HClO4, resulting in a heterogeneous and reusable catalyst for the Biginelli reaction. In the absence of the catalyst, the reaction provided a yield of 19%. However, in the presence of HClO4-Al(2)O(3)it was possible to synthesize 16 examples of DHPMs/thiones with improved yields (80-98%), in reaction periods of 1 to 3 hours. The catalyst also stood out for its stability against temperature and the reagents used. (AU) | |
| Processo FAPESP: | 16/20155-7 - Reações de aminólise e de resolução cinética por lipases e biodegradação de agroquímicos por microrganismos |
| Beneficiário: | Andre Luiz Meleiro Porto |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 19/07654-2 - Reação de Biginelli (síntese e resolução quimioezimática) e biotransformação de esteroides por microrganismos |
| Beneficiário: | Andre Luiz Meleiro Porto |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |