| Texto completo | |
| Autor(es): |
Bernegossi, Jessica
;
Fontana, Carla Raquel
;
Caiaffa, Karina Sampaio
;
Duque, Cristiane
;
Chorilli, Marlus
Número total de Autores: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF BIOMEDICAL NANOTECHNOLOGY; v. 16, n. 3, p. 8-pg., 2020-03-01. |
| Resumo | |
KSL-W peptide has demonstrated antibacterial and antifungal activity and inhibitory effects against oral biofilm. This study aimed to check out the effect of chlorhexidine (CLX) or KSL-W peptide-loaded poloxamer 407-based microemulsions for buccal delivery on Fusobacterium nucleatum (F. nucleatum) biofilm. The formulation (F) containing 10% copolymer poloxamer 407 dispersion (1%), 40% oleic acid and 50% PPG-5-CETETH-20 was characterized by polarized light microscopy (PLM), small-angle X-ray scattering (SAXS), rheology, bioadhesive and syringeability; and in the treatment of a biofilm produced by F. nucleatum. The darkfield images obtained by PLM and the SAXS curves with an extended peak indicated that the system was characteristic of microemulsions. In a continuous analysis, microemulsions exhibited Newtonian behavior. In frequency, the oscillatory analysis profile presented predominantly viscous behavior. Bioadhesive force detected in the analysis of F (7.4 +/- 1.81 mN.s) and syringeability (17.83 +/- 5.97 N.mm) being adequate values for buccal administration. After 4 h, KSL-W-loaded F shown over 20% higher effectiveness than chlorhexidine-loaded microemulsions. In conclusion, the KSL-W-loaded microemulsions showed a considerable reduction in F. nucleatum biofilm formation and presented promising structural properties for buccal drug delivery. (AU) | |
| Processo FAPESP: | 14/22045-9 - Sistemas precursores de cristais líquidos mucoadesivos para administração bucal de curcumina associados à terapia fotodinâmica no tratamento da candidose bucal |
| Beneficiário: | Jéssica Bernegossi |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |