Autor(es)

de Amorim, Marcelo R. ; Wijeratne, E. M. Kithsiri ; Zhou, Shengliang ; Arnold, A. Elizabeth ; Batista, Andrea N. L. ; Batista, Joao M. ; dos Santos, Lourdes C. ; Gunatilaka, A. A. Leslie

• Tipo de documento: Artigo Científico
• Fonte: Tetrahedron; v. 76, n. 43, p. 9-pg., 2020-10-23.

Resumo

Incorporation of the epigenetic modifier suberoylanilide hydroxamic acid (SAHA) into a potato dextrose broth culture of the endophytic fungus Aspergillus sp. AST0006 affected its polyketide biosynthetic pathway providing two new 3-(4-oxopyrano)-chromen-2-ones, aspyranochromenones A (1) and B (2), and the isocoumarin, (-)-6,7-dihydroxymellein (3). Eight additional metabolites (4-11) and two biotransformation products of SAHA (12-13) were also encountered. The planar structures and relative configurations of the new metabolites 1-2 were elucidated with the help of high-resolution mass, 1D and 2D NMR spectroscopic data and the absolute configurations of 1-3 were determined by comparison of experimental and calculated ECD data. Possible biosynthetic pathways to 1 and 2 are presented. (C) 2020 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 18/05905-5 - Modificadores epigenéticos: ampliando a diversidade metabólica de fungos endofíticos
• Beneficiário: Marcelo Rodrigues de Amorim
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
• Processo FAPESP: 14/25222-9 - Espectroscopia quiróptica vibracional na caracterização estereoquímica de pequenas moléculas e macromoléculas
• Beneficiário: João Marcos Batista Junior
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores