Urban, traffic-related particles and lung tumors in urethane treated mice

Autor(es)

Cangerana Pereira, Fernanda Alves ^[1] ; Lemos, Miriam ^[2] ; Mauad, Thais ^[1] ; de Assuncao, Joao Vicente ^[3] ; Nascimento Saldiva, Paulo Hilario ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med, Dept Pathol, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Fac Med, Dept Surg, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Publ Hlth, Dept Environm Hlth, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Clinics; v. 66, n. 6, p. 1051-1054, 2011.
• Citações Web of Science: 6

Resumo

OBJECTIVE: The present study was designed to evaluate the effects of urban, traffic-related, fine particulate matter (PM2.5) on mice lung tumorigenesis under controlled exposure conditions. METHODS: Four groups of female Swiss mice were treated with intraperitonial injections of urethane and saline solution. Urethane was used to start the carcinogenesis process. The animals were housed in two chambers receiving filtered and polluted air. In the polluted air chamber, pollutant levels were low. After two months of exposure, the animals were euthanized and lung tumoral nodules were counted. RESULTS: Saline-treated animals showed no nodules. Urethane-treated animals showed 2.0+2.0 and 4.0+3.0 nodules respectively, in the filtered and non-filtered chambers (p = 0.02), thus showing experimental evidence of increased carcinogenic-induced lung cancer with increasing PM2.5 exposure. CONCLUSION: Our data support the concept that low levels of PM2.5 may increase the risk of developing lung tumors. (AU)

• Processo FAPESP: 08/57717-6 - Instituto Nacional de Análise Integrada de Risco Ambiental
• Beneficiário: Thais Mauad
• Modalidade de apoio: Auxílio à Pesquisa - Temático