| Texto completo | |
| Autor(es): |
Lisboa, S. F.
[1]
;
Stecchini, M. F.
[1]
;
Correa, F. M. A.
[1]
;
Guimaraes, F. S.
[1]
;
Resstel, L. B. M.
[1]
Número total de Autores: 5
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Dept Pharmacol, Sch Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP - Brazil
Número total de Afiliações: 1
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Neuroscience; v. 171, n. 3, p. 760-768, DEC 15 2010. |
| Citações Web of Science: | 34 |
| Resumo | |
Reversible inactivation of the ventral portion of medial prefrontal cortex (vMPFC) of the rat brain has been shown to induce anxiolytic-like effects in animal models based on associative learning. The role of this brain region in situations involving innate fear, however, is still poorly understood, with several contradictory results in the literature. The objective of the present work was to verify in male Wistar rats the effects of vMPFC administration of cobalt chloride (CoCl(2)), a selective inhibitor of synaptic activity, in rats submitted to two models based on innate fear, the elevated plus-maze (EPM) and light-dark box (LOB), comparing the results with those obtained in two models involving associative learning, the contextual fear conditioning (CFC) and Vogel conflict (VCT) tests. The results showed that, whereas CoCl(2) induced anxiolytic-like effects in the CFC and VCT tests, it enhanced anxiety in rats submitted to the EPM and LOB. Together these results indicate that the vMPFC plays an important but complex role in the modulation of defensive-related behaviors, which seems to depend on the nature of the anxiety/fear inducing stimuli. (C) 2010 IBRO. Published by Elsevier Ltd. All rights reserved. (AU) | |
| Processo FAPESP: | 07/06999-9 - Estudo da possível interação entre os sistemas canabinóide e nitrérgico na substância cinzenta periaquedutal dorsolateral na modulação de comportamentos defensivos em ratos |
| Beneficiário: | Sabrina Francesca de Souza Lisboa |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |