| Texto completo | |
| Autor(es): |
Ferreira, H. V.
[1]
;
Rocha, L. C.
[1]
;
Severino, R. P.
[1, 2]
;
Viana, R. B.
[1]
;
da Silva, A. B. F.
[1]
;
Porto, A. L. M.
[1]
Número total de Autores: 6
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil
[2] Univ Fed Goias, Dept Quim, BR-75704020 Catalao, Go - Brazil
Número total de Afiliações: 2
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of the Iranian Chemical Society; v. 7, n. 4, p. 883-889, DEC 2010. |
| Citações Web of Science: | 9 |
| Resumo | |
Large scale enzymatic resolution of racemic sulcatol 2 has been useful for stereoselective biocatalysis. This reaction was fast and selective, using vinyl acetate as donor of acyl group and lipase from Candida antarctica (CALB) as catalyst. The large scale reaction (5.0 g, 39 mmol) afforded high optical purities for S-(+)-sulcatol 2 and R-(+)-sulcatyl acetate 3, i.e., ee > 99 per cent and good yields (45 per cent) within a short time (40 min). Thermodynamic parameters for the chemoesterification of sulcatol 2 by vinyl acetate were evaluated. The enthalpy and Gibbs free energy values of this reaction were negative, indicating that this process is exothermic and spontaneous which is in agreement with the reaction obtained enzymatically. (AU) | |
| Processo FAPESP: | 06/54401-2 - Biocatálise e biotransformação de compostos orgânicos com fungos marinhos, algas marinhas e reações catalisadas com enzimas comerciais |
| Beneficiário: | Andre Luiz Meleiro Porto |
| Linha de fomento: | Auxílio à Pesquisa - Regular |