NF-kappa b expression predicts clinical outcome for nasal polyposis

Autor(es)

Cardoso Pereira Valera, F. ^[1] ; Queiroz, R. ^[2] ; Scrideli, C. ^[2] ; Gonzaga Tone, L. ^[2] ; Anselmo-Lima, W. T. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Ophthalmol Otorhinolaryngol & Head & Neck Su, BR-14049900 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pediat, BR-14049900 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: RHINOLOGY; v. 48, n. 4, p. 408-414, DEC 2010.
• Citações Web of Science: 9

Resumo

Objective: To correlate clinical prognosis of patients with nasal polyps to the expression of p65, c-Fos, GR alpha and GR beta. Methods: A biopsy was obtained at the first evaluation of patients with nasal polyps, and at rhinoplasty for control mucosa. Patients with nasal polyps were treated with glucocorticoids and followed for at least 60 months. The expression of p65, c-Fos, GR alpha and GR beta was determined by Real Time-PCR and correlated to clinical outcome. The end-point of resistance to glucocorticoid therapy was considered when surgery was indicated. Results: Patients with nasal polyps presented a higher expression of p65, a lower expression of GR alpha, and a lower GR alpha/GR beta ratio than control mucosa. The patients with nasal polyps who had a higher expression of p65 correlated with a poorer response to glucocorticoids, with a 3.5-fold higher risk for surgery. Conclusion: Patients with a higher p65 (NF-kappa B) expression at diagnosis were associated to a worse response to clinical treatment, suggesting one of the mechanisms of cell resistance to glucocorticoid treatment in patients with nasal polyps. (AU)

• Processo FAPESP: 03/12439-5 - Expressão dos genes de receptores de corticosteroides GR alfa e GR beta e de fatores de transcrição AP-1 e NF-kappaB em pacientes com polipose nasossinusal: avaliação de mecanismos de resistência ao corticosteroide
• Beneficiário: Wilma Terezinha Anselmo Lima
• Modalidade de apoio: Auxílio à Pesquisa - Regular