Approach on the Electrochemical Reactivity of Poly-L-Glutamic Acid Against Doxorubicin and Its Application in the Development of a Voltammetric Sensor

Autor(es)

dos Santos, Daniela Pereira ^[1] ; Bergamini, Marcio Fernando ^[2] ; Boldrin Zanoni, Maria Valnice ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo State, Inst Chem, UNESP, BR-14801970 Araraquara, SP - Brazil

^[2] UFPR, Ctr Politecn, Setor Ciencias Exatas, Dept Quim, BR-81531990 Curitiba, Parana - Brazil

• Tipo de documento: Artigo Científico
• Fonte: International Journal of Electrochemical Science; v. 5, n. 10, p. 1399-1410, OCT 2010.
• Citações Web of Science: 7

Resumo

The poly-L-glutamic acid (PGA), was used a biodegradable polymers as conjugated to doxorubicin (DXR) and also in the modification glassy carbon electrode. The interaction operate via terminal amino groups of the drug and the side chain carboxyl groups of branched PGA film and it is the base to develop a simple voltammetric sensor for the determination of doxorubicin in human urine. The preconcentration of DXR on the modified electrode occurs under open circuit and studied by the methods of square wave voltammetry to monitor the drug. Standard curves were linear over the concentration range of 2.20 - 44.5 mu mol L(-1) giving a detection limit of 0.45 mu mol L(-1) show that the proposed sensor is suitable for doxorubicin determination in real samples. (AU)

• Processo FAPESP: 04/00111-8 - Desenvolvimento e aplicação de sensores eletroquímicos baseados em filmes poliméricos de poli-L-histidina
• Beneficiário: Marcio Fernando Bergamini
• Modalidade de apoio: Bolsas no Brasil - Doutorado