Mutagenicity and cytotoxicity assessment in patients undergoing orthodontic radiographs

Autor(es)

Angelieri, F. ^[1] ; Carlin, V. ^[2] ; Saez, D. M. ^[1] ; Pozzi, R. ^[3] ; Ribeiro, D. A. ^{[2, 3]}

Afiliação do(s) autor(es)

^[1] Sao Paulo Methodist Univ, Dept Orthodont, UMESP, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Dept Pathol, Paulista Med Sch, Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo, Dept Biosci, UNIFESP, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Dentomaxillofacial Radiology; v. 39, n. 7, p. 437-440, OCT 2010.
• Citações Web of Science: 17

Resumo

Objectives: The aim of the present study was to evaluate DNA damage (micronucleus) and cellular death (pyknosis, karyolysis and karyorrhexis) in exfoliated buccal mucosa cells from individuals following radiography. Methods: Lateral and frontal cephalometric X-ray and panoramic dental X-rays were taken of a total of 18 healthy patients (6 male and 12 female) referred for orthodontic therapy. Exfoliated oral mucosa cells were collected immediately before X-ray exposure and after 10 days. Results: The results revealed no statistically significant difference (P > 0.05) in the frequency micronucleated oral mucosa cells after X-ray exposure. However, X-ray was able to increase other nuclear alterations closely related to cytotoxicity, such as karyorrhexis, pyknosis and karyolysis. Conclusions: Data indicated that exposure to certain radiography may not be a factor in inducing chromosomal damage, but it does promote cytotoxicity. Dentomaxillofacial Radiology (2010) 39, 437-440. doi: 10.1259/dmfr/24791952 (AU)

• Processo FAPESP: 07/01228-4 - Carcinogênese bucal quimicamente induzida pela 4-nitroquinolina 1-óxido em ratos: possíveis biomarcadores envolvidos em sua patogênese
• Beneficiário: Daniel Araki Ribeiro
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores