| Texto completo | |
| Autor(es): |
Martins, Antonio Henrique B.
;
Pesquero, João Bosco
;
Ulrich, Alexander Henning
[3]
Número total de Autores: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Cytometry Part A; v. 59A, n. 2, p. 220-231, Jun. 2004. |
| Área do conhecimento: | Ciências Biológicas - Bioquímica |
| Assunto(s): | Proteínas |
| Resumo | |
The systematic evolution of ligands by exponential enrichment (SELEX) technique is a combinatorial library approach in which DNA or RNA molecules (aptamers) are selected by their ability to bind their protein targets with high affinity and specificity, comparable to that of monoclonal antibodies. In contrast to antibodies conventionally selected in animals, aptamers are generated by an in vitro selection process, and can be directed against almost every target, including antigens like toxins or nonimmunogenic targets, against which conventional antibodies cannot be raised. (AU) | |