| Full text | |
| Author(s): |
Martins, Antonio Henrique B.
;
Pesquero, João Bosco
;
Ulrich, Alexander Henning
[3]
Total Authors: 3
|
| Document type: | Journal article |
| Source: | Cytometry Part A; v. 59A, n. 2, p. 220-231, Jun. 2004. |
| Field of knowledge: | Biological Sciences - Biochemistry |
| Abstract | |
The systematic evolution of ligands by exponential enrichment (SELEX) technique is a combinatorial library approach in which DNA or RNA molecules (aptamers) are selected by their ability to bind their protein targets with high affinity and specificity, comparable to that of monoclonal antibodies. In contrast to antibodies conventionally selected in animals, aptamers are generated by an in vitro selection process, and can be directed against almost every target, including antigens like toxins or nonimmunogenic targets, against which conventional antibodies cannot be raised. (AU) | |