Anti-Inflammatory Effects of Low-Level Light Emitting Diode Therapy on Achilles Tendinitis in Rats

Autor(es)

Xavier, Murilo ^{[1, 2]} ; David, Debora Rodrigues ^[1] ; de Souza, Renato Aparecido ^{[1, 2]} ; Arrieiro, Arthur Nascimento ^[2] ; Miranda, Humberto ^[1] ; Santana, Eduardo Tadeu ^[3] ; Silva, Jr., Jose Antonio ^[3] ; Castillo Salgado, Miguel Angel ^[4] ; Aimbire, Flavio ^[5] ; Albertini, Regiane ^[5]

Afiliação do(s) autor(es)

^[1] Vale Paraiba Univ, Inst Res & Dev, IP&D, BR-12244000 Sao Paulo - Brazil

^[2] Univ Fed Vales Jequitinhonha & Mucuri, Dept Phys Therapy, BR-39100000 Diamantina, MG - Brazil

^[3] Ctr Univ Nove de Julho, Dept Ciencias Reabilitacao, Sao Paulo - Brazil

^[4] Univ Estadual Paulista, Fac Odontol, Sao Paulo - Brazil

^[5] Univ Camilo Castelo Branco, BR-116 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Lasers in Surgery and Medicine; v. 42, n. 6, p. 553-558, AUG 2010.
• Citações Web of Science: 52

Resumo

Background and Objectives: The present study investigated the effects of low-level light emitting diode (LED) therapy (880 +/- 10 nm) on inflammatory process in a experimental model of Achilles tendinitis induced by collagenase. Study Design/Materials and Methods: Fifty-six male Wistar were separated into seven groups (n = 8), three groups in the experimental period of 7 days and four groups in the experimental period of 14 days, the control group (CONT), tendinitis group (TEND), LED therapy group (LEDT) for both experimental periods, and LED therapy group 7th to 14th day (LEDT delay) for 14 days experimental period. The LED parameters was 22 mW CW of optical output power, distributed in an irradiation area of 0.5 cm(2), with an irradiation time of 170 seconds, the applied energy density was 7.5 J/cm(2) in contact. The therapy was initiated 12 hours after the tendinitis induction, with a 48-hour interval between the irradiations. The histological analysis and inflammatory mediators were quantified Results: Our results showed that LED decreases the inflammatory cells influx and mRNA expression to IL-1 beta, IL-6, tumor necrosis factor-alpha (TNF-alpha) in both phase, and cyclooxygenase-2 (COX-2) just in initial phase (P < 0 05). Conclusion: Our results suggest that the anti-inflammatory therapy with low-power LED (880 nm) enhanced the tissue response in all groups We can conclude that the LED was able to reduce signs of inflammation in collagenase-induced tendinitis in rats by reducing the number of inflammatory cells and decrease mRNA expression of cytokines Lasers Surg. Med. 42:553-558, 2010 (C) 2010 Wiley-Liss, Inc. (AU)

• Processo FAPESP: 07/02596-7 - Analise do mecanismo de acao da terapia laser de baixa potencia em modelo experimental de inflamacao cronica.
• Beneficiário: Regiane Albertini
• Modalidade de apoio: Auxílio à Pesquisa - Regular