Study of growth factors and receptors in carcinoma ex pleomorphic adenoma

Autor(es)

Furuse, Cristiane ^[1] ; Miguita, Lucyene ^[1] ; Garcia Rosa, Ana Claudia ^[1] ; Soares, Andresa Borges ^[1] ; Martinez, Elizabeth Ferreira ^[1] ; Altemani, Albina ^[2] ; de Araujo, Vera Cavalcanti ^[1]

Afiliação do(s) autor(es)

^[1] Sao Leopoldo Mand Inst & Res Ctr, Dept Oral Pathol, Sao Paulo - Brazil

^[2] State Univ Campinas UNICAMP, Dept Pathol, Sch Med, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: JOURNAL OF ORAL PATHOLOGY & MEDICINE; v. 39, n. 7, p. 540-547, AUG 2010.
• Citações Web of Science: 12

Resumo

P>Carcinoma ex pleomorphic adenoma (CXPA) is a rare malignant salivary gland tumor derived from a pre-existing pleomorphic adenoma. It is a good model to study the evolution of carcinogenesis, starting with in situ areas to frankly invasive carcinoma. Growth factors are associated with several biological and neoplastic processes by transmembrane receptors. In order to investigate, by immunohistochemistry, the expression of some growth factors and its receptors {[}EGF receptor, fibroblast growth factor, fibroblast growth factor receptor 1, fibroblast growth factor receptor 2, hepatocyte growth factor, c-Met, transforming growth factor (TGF) beta 1, TGF beta R-II and insulin-like growth factor receptor 1] in the progression of CXPA, we have used ten cases of CXPA in several degrees of invasion- intracapsular, minimally and frankly invasive carcinoma- with only epithelial component. Slides were qualitatively and semi-quantitatively evaluated according to the percentage of stained tumor cells from 0 to 3 (0 = less than 10%; 1 = 10-25%; 2 = 25-50%; 3 = more than 50% of cells). Malignant epithelial cells starting with in situ areas showed stronger expression than luminal cells of pleomorphic adenoma for all antibodies. Most of the intracapsular, minimally and frankly invasive CXPA presented score 3. However, score 2 was more evident in the frankly invasive one. In small nests of invasive carcinoma, negative cells were observed probably indicating that the proliferative process is replaced by the invasive mechanism. Altogether this data infers that these factors may contribute to cell proliferation during initial phases of the tumor. (AU)

• Processo FAPESP: 04/07960-0 - Estudo das alterações ocorridas no adenoma durante o processo de malignização em carcinoma ex-adenoma pleomórfico
• Beneficiário: Vera Cavalcanti de Araujo
• Modalidade de apoio: Auxílio à Pesquisa - Temático