Predictors of restenosis after percutaneous coronary intervention using bare-metal stents. A comparison between patients with and without dysglycemia

Autor(es)

Lima-Filho, M. O. ^[1] ; Figueiredo, G. L. ^[1] ; Foss-Freitas, M. C. ^[2] ; Foss, M. C. ^[2] ; Marin-Neto, J. A. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Clin Med, Div Cardiol, BR-14048900 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Clin Med, Div Endocrinol, BR-14048900 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Medical and Biological Research; v. 43, n. 6, p. 572-579, JUN 2010.
• Citações Web of Science: 9

Resumo

The objective of this study was to identify intravascular ultrasound (IVUS), angiographic and metabolic parameters related to restenosis in patients with dysglycemia. Seventy consecutive patients (77 lesions) selected according to inclusion and exclusion criteria were evaluated by the oral glucose tolerance test and the determination of insulinemia after a successful percutaneous coronary intervention (PCI) with a bare-metal stent. The degree of insulin resistance was calculated by the homeostasis model assessment of insulin resistance (HOMA-IR). Six-month IVUS and angiogram follow-up were performed. Thirty-nine patients (55.7%) had dysglycemia. The restenosis rate in the dysglycemic group was 37.2 vs 23.5% in the euglycemic group (P = 0.299). The predictors of restenosis using bivariate analysis were reference vessel diameter (RVD): <= 2.93 mm (RR = 0.54; 95% CI = 0.05-0.78; P = 0.048), stent area (SA): <8.91 mm(2) (RR = 0.66; 95% CI = 0.24-0.85; P = 0.006), stent volume (SV): <119.75 mm(3) (RR = 0.74; 95% CI = 0.38-0.89; P = 0.0005), HOMA-IR: >2.063 (RR = 0.44; 95% CI = 0.14-0.64; P = 0.027), and fasting plasma glucose (FPG): <= 108.8 mg/dL (RR = 0.53; 95% CI = 0.13-0.75; P = 0.046). SV was an independent predictor of restenosis by multivariable analysis. Dysglycemia is a common clinical condition in patients submitted to PCI. The degree of insulin resistance, FPG, RVD, SA, and SV were correlated with restenosis. SV was inversely correlated with an independent predictor of restenosis in patients treated with a bare-metal stent. (AU)

• Processo FAPESP: 99/07143-2 - Avaliação pelo ultrassom intravascular e pela análise angiográfica quantitativa da hiperproliferação miointimal após angioplastia coronária com endopróteses ("STENTS") em pacientes disglicêmicos e normoglicêmicos
• Beneficiário: José Antonio Marin-Neto
• Modalidade de apoio: Auxílio à Pesquisa - Regular