| Texto completo | |
| Autor(es): |
Chiba, Fernando Yamamoto
[1]
;
Colombo, Natalia Helena
[1]
;
Shirakashi, Daisy Jaqueline
[1]
;
de Souza Gomes, Wendrew Douglas
[1]
;
Saliba Moimaz, Suzely Adas
[2]
;
Saliba Garbin, Clea Adas
[2]
;
Silva, Cristina Antoniali
[1]
;
Sumida, Doris Hissako
[1]
Número total de Autores: 8
|
| Afiliação do(s) autor(es): | [1] Univ Estadual Paulista, Dent Sch Aracatuba, Dept Basic Sci, UNESP, BR-16015050 Aracatuba, SP - Brazil
[2] Univ Estadual Paulista, Dept Child & Social Dent, Dent Sch Aracatuba, UNESP, BR-16015050 Aracatuba, SP - Brazil
Número total de Afiliações: 2
|
| Tipo de documento: | Artigo Científico |
| Fonte: | FLUORIDE; v. 43, n. 1, p. 25-30, JAN-MAR 2010. |
| Citações Web of Science: | 13 |
| Resumo | |
With half the animals as controls without fluoride (F) in their drinking water, 16 of 32 seven-week-old castrated male Wistar rats were administered NaF in their drinking water and F contained in food pellets (estimated total F intake: 4.0 mg F/kg bw/day). After 42 days, determinations were made of the insulin receptor substrate (pp185-IRS-1/IRS/2), tyrosine phosphorylation status, and the extent of glycemia and insulinemia. This chronic treatment with F promoted: 1) decrease in the pp185 tyrosine phosphorylation status in the muscle tissue but not in the liver; 2) increase in the plasma F level; 3) no alteration in glycemia and insulinemia; 4) an increase in insulin resistance. (AU) | |
| Processo FAPESP: | 08/52688-8 - Avaliacao da etapa inicial do sinal insulinico em tecido muscular e hepatico de ratos tratados cronicamente com naf. |
| Beneficiário: | Fernando Yamamoto Chiba |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |