| Full text | |
| Author(s): |
Chiba, Fernando Yamamoto
[1]
;
Colombo, Natalia Helena
[1]
;
Shirakashi, Daisy Jaqueline
[1]
;
de Souza Gomes, Wendrew Douglas
[1]
;
Saliba Moimaz, Suzely Adas
[2]
;
Saliba Garbin, Clea Adas
[2]
;
Silva, Cristina Antoniali
[1]
;
Sumida, Doris Hissako
[1]
Total Authors: 8
|
| Affiliation: | [1] Univ Estadual Paulista, Dent Sch Aracatuba, Dept Basic Sci, UNESP, BR-16015050 Aracatuba, SP - Brazil
[2] Univ Estadual Paulista, Dept Child & Social Dent, Dent Sch Aracatuba, UNESP, BR-16015050 Aracatuba, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | FLUORIDE; v. 43, n. 1, p. 25-30, JAN-MAR 2010. |
| Web of Science Citations: | 13 |
| Abstract | |
With half the animals as controls without fluoride (F) in their drinking water, 16 of 32 seven-week-old castrated male Wistar rats were administered NaF in their drinking water and F contained in food pellets (estimated total F intake: 4.0 mg F/kg bw/day). After 42 days, determinations were made of the insulin receptor substrate (pp185-IRS-1/IRS/2), tyrosine phosphorylation status, and the extent of glycemia and insulinemia. This chronic treatment with F promoted: 1) decrease in the pp185 tyrosine phosphorylation status in the muscle tissue but not in the liver; 2) increase in the plasma F level; 3) no alteration in glycemia and insulinemia; 4) an increase in insulin resistance. (AU) | |