Genetic profile of adenoid cystic carcinomas (ACC) with high-grade transformation versus solid type

Autor(es)

Costa, Ana Flavia ^[1] ; Altemani, Albina ^[1] ; Vekony, Hedy ^[2] ; Bloemena, Elisabeth ^[2] ; Fresno, Florentino ^[3] ; Suarez, Carlos ^[4] ; Llorente, Jose Luis ^[4] ; Hermsen, Mario ^[4]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Dept Pathol, Campinas - Brazil

^[2] Vrije Univ Amsterdam, Med Ctr, Dept Pathol, Amsterdam - Netherlands

^[3] Hosp Univ Cent Asturias, Dept Pathol, IUOPA, Oviedo - Spain

^[4] Hosp Univ Cent Asturias, Dept Otolaryngol, IUOPA, Oviedo - Spain

• Tipo de documento: Artigo Científico
• Fonte: ANALYTICAL CELLULAR PATHOLOGY; v. 33, n. 5-6, p. 217-228, 2010.
• Citações Web of Science: 6

Resumo

Background: ACC can occasionally undergo dedifferentiation also referred to as high-grade transformation (ACC-HGT). However, ACC-HGT can also undergo transformation to adenocarcinomas which are not poorly differentiated. ACC-HGT is generally considered to be an aggressive variant of ACC, even more than solid ACC. This study was aimed to describe the genetic changes of ACC-HGT in relation to clinico-pathological features and to compare results to solid ACC. Methods: Genome-wide DNA copy number changes were analyzed by microarray CGH in ACC-HGT, 4 with transformation into moderately differentiated adenocarcinoma (MDA) and two into poorly differentiated carcinoma (PDC), 5 solid ACC. In addition, Ki-67 index and p53 immunopositivity was assessed. Results: ACC-HGT carried fewer copy number changes compared to solid ACC. Two ACC-HGT cases harboured a breakpoint at 6q23, near the cMYB oncogene. The complexity of the genomic profile concurred with the clinical course of the patient. Among the ACC-HGT, p53 positivity significantly increased from the conventional to the transformed (both MDA and PDC) component. Conclusion: ACC-HGT may not necessarily reflect a more advanced stage of tumor progression, but rather a transformation to another histological form in which the poorly differentiated forms (PDC) presents a genetic complexity similar to the solid ACC. (AU)

• Processo FAPESP: 09/54377-2 - Identificação das alterações genéticas e epigenéticas no carcinoma adenoide cístico com transformação para alto grau
• Beneficiário: Ana Flávia de Mattos Costa
• Modalidade de apoio: Bolsas no Brasil - Doutorado