Beta-2 adrenergic receptor gene polymorphisms Gln27Glu, Arg16Gly in patients with heart failure

Autor(es)

Mansur, Alfredo Jose ^[1] ; Fontes, Rosana Seleri ^[1] ; Canzi, Regina Airoldi ^[1] ; Nishimura, Raphael ^[2] ; Alencar, Airlane Pereira ^[2] ; Pedroso de Lima, Antonio Carlos ^[2] ; Krieger, Jose Eduardo ^[1] ; Pereira, Alexandre Costa ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med, Heart Inst InCor, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Inst Math & Stat, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BMC CARDIOVASCULAR DISORDERS; v. 9, NOV 3 2009.
• Citações Web of Science: 8

Resumo

Background -: Beta-2 adrenergic receptor gene polymorphisms Gln27Glu, Arg16Gly and Thr164Ile were suggested to have an effect in heart failure. We evaluated these polymorphisms relative to clinical characteristics and prognosis of alarge cohort of patients with heart failure of different etiologies. Methods -: We studied 501 patients with heart failure of different etiologies. Mean age was 58 years (standard deviation 14.4 years), 298 (60%) were men. Polymorphisms were identified by polymerase chain reaction-restriction fragment length polymorphism. Results -: During the mean follow-up of 12.6 months (standard deviation 10.3 months), 188 (38%) patients died. Distribution of genotypes of polymorphism Arg16Gly was different relative to body mass index (chi(2) = 9.797; p = 0.04). Overall the probability of survival was not significantly predicted by genotypes of Gln27Glu, Arg16Gly, or Thr164Ile. Allele and haplotype analysis also did not disclose any significant difference regarding mortality. Exploratory analysis through classification trees pointed towards a potential association between the Gln27Glu polymorphism and mortality in older individuals. Conclusion -: In this study sample, we were not able to demonstrate an overall influence of polymorphisms Gln27Glu and Arg16Gly of beta-2 receptor gene on prognosis. Nevertheless, Gln27Glu polymorphism may have a potential predictive value in older individuals. (AU)

• Processo FAPESP: 01/14045-9 - Polimorfismos genicos dos receptores beta-adrenergicos em portadores de insuficiencia cardiaca.
• Beneficiário: Rosana Seleri Fontes
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica