B-1 cell: the precursor of a novel mononuclear phagocyte with immuno-regulatory properties

Autor(es)

Lopes, Jose Daniel ^[1] ; Mariano, Mario ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Microbiol Imunol & Parasitol, BR-04023900 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Anais da Academia Brasileira de Ciências; v. 81, n. 3, p. 489-496, SEP 2009.
• Citações Web of Science: 9

Resumo

Characterization of the origin, properties, functions and fate of cells is a fundamental task for the understanding of physiological and pathological phenomena. Despite the bulk of knowledge concerning the diverse characteristics of mammalian cells, some of them, such as B-1 cells, are still poorly understood. Here we report the results obtained in our laboratory on these cells in the last 10 years. After showing that B-1 cells could be cultured and amplified in vitro, a series of experiments were performed with these cells. They showed that B1 cells reside mostly in the peritoneal and pleural cavities, migrate to distant inflammatory foci, coalesce to form giant cells and participate in granuloma formation, both in vitro and in vivo. They are also able to present antigens to immunologically responsive cells and are endowed with regulatory properties. Further, we have also shown that these cells facilitate different types of infection as well as tumor growth and spreading. These data are presently reviewed pointing to a pivotal role that these cells may play in innate and acquired immunity. (AU)

• Processo FAPESP: 07/51501-9 - Células B-1 e sua participação nos modelos experimentais de melanoma murino e infecção por Paracoccidioides brasiliensis
• Beneficiário: José Daniel Lopes
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 04/08506-1 - Células B-1: origem, diferenciação e participação na inflamação, cicatrização e rejeição de enxerto
• Beneficiário: Mario Mariano
• Modalidade de apoio: Auxílio à Pesquisa - Temático