Could the treatment of differentiated thyroid carcinoma with 3.7 and 5.55 GBq of (I-131)NaI, on an outpatient basis, be safe?

Autor(es)

de Amorim de Carvalho, Jose Willegaignon ^{[1, 2]} ; Sapienza, Marcelo ^[2] ; Ono, Carla ^[2] ; Watanabe, Tomoco ^[2] ; Guimaraes, Maria Ines ^[2] ; Gutterres, Ricardo ^[3] ; Marechal, Maria Helena ^[3] ; Buchpiguel, Carlos ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Ctr Med Nucl, Inst Radiol, Hosp Clin, Fac Med, Dep Radiol, Sch Med, BR-05403010 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Med, LIM 43, Clin Hosp, BR-05403010 Sao Paulo - Brazil

^[3] CNEN, Rio De Janeiro - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NUCLEAR MEDICINE COMMUNICATIONS; v. 30, n. 7, p. 533-541, JUL 2009.
• Citações Web of Science: 15

Resumo

Objectives The first objective of this study was to evaluate the radiological impact on relatives and the environment because of outpatient treatment of differentiated thyroid carcinoma with 3.7 and 5.55 GBq of ((131)I)NaI. The second objective was to determine, analyze, and evaluate whole-body radiation dose to caregivers, the production of contaminated solid waste, and the potentiality of radiation dose and surface contamination existing inside patients' households. Methods Twenty patients were treated on an outpatient basis, taking into consideration their acceptable living conditions, interests, and willingness to comply with medical and radiation-safety guidelines. The caregivers themselves, as well as the potentiality of the radiation dose inside patients' residences, were monitored with a thermo-luminescence dosimeter. Surface contamination and contaminated solid wastes were identified and measured by using a Geiger-Muller detector. Results and discussion Twenty-six monitored individuals received accumulated effective radiation doses of less than 1.0 mSv, and only one 2.8 mSv, throughout the 7 days of measurement. The maximum registered value for the potential of radiation dose inside all living areas was 1.30 mSv. The monitored surface contamination inside patients' dwellings showed a mean value of 4.2 Bq/cm(2) for all surfaces found to be contaminated. A total of 2.5l of contaminated solid waste was generated by the patients with 3.33 MBq of all estimated activity. Conclusion This study revealed that the treatment of differentiated thyroid carcinoma with 3.7 and 5.55 GBq of ((131)I)NaI, on an outpatient basis, can be safe when overseen by qualified professionals and with an adapted radiation-protection guideline. Even considering the radioiodine activity level and the dosimetric methodology applied here, negligible human exposure and a nonmeasurable radiological impact to the human environment were found. Nucl Med Commun 30:533-541 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams \& Wilkins. (AU)

• Processo FAPESP: 06/61556-2 - Avaliação dosimétrica do tratamento ambulatorial do carcinoma da tireóide com atividades de 100 a 150 mCi de iodo-131
• Beneficiário: Carlos Alberto Buchpiguel
• Modalidade de apoio: Auxílio à Pesquisa - Pesquisa em Políticas Públicas para o SUS