Can eccentric arterial plaques alone cause flow stagnation points and favour thrombus incorporation?

Autor(es)

Beneli, Cristina T. ^[1] ; Barbosa, Priscila F. ^[1] ; Floriano, Elaine M. ^[1] ; Abreu, Monica A. ^[1] ; Ramalho, Fernando S. ^[2] ; Elias Junior, Jorge ^[3] ; Rossi, Marcos A. ^[1] ; Ramos, Simone G. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Pathol, Fac Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Dept Surg & Anat, Fac Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP - Brazil

^[3] Univ Sao Paulo, Dept Radiol, Fac Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: International Journal of Experimental Pathology; v. 90, n. 3, p. 295-310, JUN 2009.
• Citações Web of Science: 1

Resumo

We have used an experimental model of aorta stenosis, with a Plexiglas plug, simulating a stable atheromatous plaque that promotes local turbulence and thrombosis. With animal survival of more than 24 h, we followed the partial fibrinolysis of the thrombus as well as its posterior organization and incorporation to the arterial wall as a neointima for up to 30 days. The mushroom plug form permitted the development of recirculation and stasis areas around it, favouring this evolution. Despite noted limitations, this study demonstrates that thrombus incorporation can contribute to plaque extension, as it can promote recirculation and stasis areas. (AU)

• Processo FAPESP: 01/09879-8 - Endotélio vascular, forças hemodinâmicas, hipertensão e aterogênese
• Beneficiário: Marcos Antonio Rossi
• Modalidade de apoio: Auxílio à Pesquisa - Regular