Estrogen Receptor-alpha Polymorphisms and Predisposition to TMJ Disorder

Autor(es)

Ribeiro-Dasilva, Margarete Cristiane ^[1] ; Peres Line, Sergio Roberto ^[2] ; Leme Godoy dos Santos, Maria Cristina ^[2] ; Arthuri, Mariana Trevisani ^[3] ; Hou, Wei ^[4] ; Fillingim, Roger Benton ^[1] ; Rizzatti Barbosa, Celia Marisa ^[5]

Afiliação do(s) autor(es)

^[1] Univ Florida, Dept Community Dent & Behav Sci, Gainesville, FL - USA

^[2] State Univ Campinas Unicamp, Dent Coll Piracicaba, Dept Morphol, Sao Paulo - Brazil

^[3] State Univ Campinas Unicamp, Dent Coll Piracicaba, Dept Physiol, Sao Paulo - Brazil

^[4] Univ Florida, Dept Epidemiol & Hlth Policy Res, Gainesville, FL - USA

^[5] State Univ Campinas Unicamp, Dept Prosthesis & Periodontol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF PAIN; v. 10, n. 5, p. 527-533, MAY 2009.
• Citações Web of Science: 48

Resumo

Temporomandibular joint disorders (TMJD) affect women with greater frequency than men, and sex hormones may contribute to this female predominance. Therefore, this study investigated whether estrogen receptor-alpha (Xbal/Pvull) single nucleotide polymorphisms (SNPs) are associated with TMJD in women. DNA was obtained from 200 women with TMJD (100 with chronic pain and 100 with signs of TMJD but no pain) diagnosed according to the Research Diagnostic Criteria for Temporomandibular Disorder (RDC/TMD) and 100 control women without TMJD. Restriction fragment length polymorphisms of polymerase chain reaction products were used to analyze Xbal and Pvull SNPs in DNA fragments. A model directly characterizing specific DNA sequence variants based on the risk haplotypic structure implemented with the EM algorithm was used to analyze the data. The {[}GC] haplotype of the Xbal locus was significantly more prevalent in both TMJD groups when compared with the control group (P = .0012). Specifically, the {[}GC] haplotype was more prevalent within the painful TMJD group versus the control group (OR 3.203, 95% CI = 1.633, 6.284) and in the TMJD no pain versus the control group (OR = 2.51, 95% CI 1.267, 4.97). In conclusion, the presence of {[}GC] haplotype in the Xbal locus may increase the susceptibility of women to develop TMJD. Perspective: This study suggests that a polymorphism in the estrogen receptor may increase the risk of women developing temporomandibular joint disorder. This finding may elucidate the interindividual differences in the contribution of estrogen to TMJD, the genetic influences on TMJD predisposition, and may serve as the basis for future treatment tailoring, which could enhance outcomes for these patients. (C) 2009 by the American Pain Society (AU)

• Processo FAPESP: 04/07258-4 - Analise de polimorfismo em gene receptor alfa de estrogeno em mulheres com sinais e sintomas de disfuncao temporomandibular.
• Beneficiário: Celia Marisa Rizzatti Barbosa
• Modalidade de apoio: Auxílio à Pesquisa - Regular