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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Estrogen Receptor-alpha Polymorphisms and Predisposition to TMJ Disorder

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Author(s):
Ribeiro-Dasilva, Margarete Cristiane [1] ; Peres Line, Sergio Roberto [2] ; Leme Godoy dos Santos, Maria Cristina [2] ; Arthuri, Mariana Trevisani [3] ; Hou, Wei [4] ; Fillingim, Roger Benton [1] ; Rizzatti Barbosa, Celia Marisa [5]
Total Authors: 7
Affiliation:
[1] Univ Florida, Dept Community Dent & Behav Sci, Gainesville, FL - USA
[2] State Univ Campinas Unicamp, Dent Coll Piracicaba, Dept Morphol, Sao Paulo - Brazil
[3] State Univ Campinas Unicamp, Dent Coll Piracicaba, Dept Physiol, Sao Paulo - Brazil
[4] Univ Florida, Dept Epidemiol & Hlth Policy Res, Gainesville, FL - USA
[5] State Univ Campinas Unicamp, Dept Prosthesis & Periodontol, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: JOURNAL OF PAIN; v. 10, n. 5, p. 527-533, MAY 2009.
Web of Science Citations: 48
Abstract

Temporomandibular joint disorders (TMJD) affect women with greater frequency than men, and sex hormones may contribute to this female predominance. Therefore, this study investigated whether estrogen receptor-alpha (Xbal/Pvull) single nucleotide polymorphisms (SNPs) are associated with TMJD in women. DNA was obtained from 200 women with TMJD (100 with chronic pain and 100 with signs of TMJD but no pain) diagnosed according to the Research Diagnostic Criteria for Temporomandibular Disorder (RDC/TMD) and 100 control women without TMJD. Restriction fragment length polymorphisms of polymerase chain reaction products were used to analyze Xbal and Pvull SNPs in DNA fragments. A model directly characterizing specific DNA sequence variants based on the risk haplotypic structure implemented with the EM algorithm was used to analyze the data. The {[}GC] haplotype of the Xbal locus was significantly more prevalent in both TMJD groups when compared with the control group (P = .0012). Specifically, the {[}GC] haplotype was more prevalent within the painful TMJD group versus the control group (OR 3.203, 95% CI = 1.633, 6.284) and in the TMJD no pain versus the control group (OR = 2.51, 95% CI 1.267, 4.97). In conclusion, the presence of {[}GC] haplotype in the Xbal locus may increase the susceptibility of women to develop TMJD. Perspective: This study suggests that a polymorphism in the estrogen receptor may increase the risk of women developing temporomandibular joint disorder. This finding may elucidate the interindividual differences in the contribution of estrogen to TMJD, the genetic influences on TMJD predisposition, and may serve as the basis for future treatment tailoring, which could enhance outcomes for these patients. (C) 2009 by the American Pain Society (AU)