| Texto completo | |
| Autor(es): |
da Silva, Claudio Vieira
[1, 2]
;
da Silva, Erika Alves
[1]
;
Cruz, Mario Costa
[1]
;
Chavrier, Philippe
[3]
;
Mortara, Renato Arruda
[1]
Número total de Autores: 5
|
| Afiliação do(s) autor(es): | [1] Univ Fed Sao Paulo, Dept Microbiol Imunol & Parasitol, BR-04023062 Sao Paulo - Brazil
[2] Univ Fed Uberlandia, Inst Ciencias Biomed, BR-38400902 Uberlandia, MG - Brazil
[3] Inst Curie, CNRS, UMR144, F-75248 Paris - France
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Biochemical and Biophysical Research Communications; v. 378, n. 3, p. 656-661, JAN 16 2009. |
| Citações Web of Science: | 16 |
| Resumo | |
Toxoplasma gondii infects a variety of different cell types in a range of different hosts. Host cell invasion by T. gondii occurs by active penetration of the host cell, a process previously described as independent of host actin polymerization. Also, the parasitophorous vacuole has been shown to resist fusion with endocytic and exocytic pathways of the host cell. ADP-ribosylation factor-6 (ARF6) belongs to the ARE family of small GTP-binding proteins. ARF6 regulates membrane trafficking and actin cytoskeleton rearrangements at the plasma membrane. Here, we have observed that ARF6 is recruited to the parasitophorous vacuole of tachyzoites of T. gondii RH strain and it also plays an important role in the parasite cell invasion with activation of PI3-kinase and recruitment of PIP(2) and PIP(3) to the parasitophorous vacuole of invading parasites. Moreover, it was verified that maintenance of host cell actin cytoskeleton integrity is important to parasite invasion. (C) 2008 Elsevier Inc. All rights reserved. (AU) | |
| Processo FAPESP: | 07/54300-4 - Estudo dos componentes do parasita e da célula hospedeira mobilizados durante a invasão e tráfego intracelular por tripomastigotas metacíclicos e amastigotas extracelulares de Trypanosoma cruzi |
| Beneficiário: | Claudio Vieira da Silva |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |