HIV-GB virus C co-infection: an overview

Autor(es)

Baggio-Zappia, Giovana Lotici ^[1] ; Hernandes Granato, Celso Francisco ^[2]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Lab Virol & Immunol 1, Virol Lab, Infect Dis Discipline, BR-04038032 Sao Paulo - Brazil

^[2] Fleury Med & Hlth, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: CLINICAL CHEMISTRY AND LABORATORY MEDICINE; v. 47, n. 1, p. 12-19, JAN 2009.
• Citações Web of Science: 10

Resumo

GB virus C (GBV-C) and hepatitis G virus (HGV) are two isolates of the same virus, independently identified in humans in the 1990s by two research laboratories, and were initially considered a potential cause of liver disease. Studies failed to associate the virus with hepatitis or any known human disease. GBV-C reappeared in the scientific scene when some research groups, in an attempt to find the interference of the virus among HIV seropositive patients, reported a lower mortality rate and slower disease progression among co-infected patients. From then on, several mechanisms have been proposed to clarify this putative benefit; however, the question whether GBV-C exerts a protective effect in HIV-infected patients remains to be resolved. (AU)

• Processo FAPESP: 05/58901-7 - Avaliação de parâmetros da resposta imunológica na co-infecção pelo HIV-1 e vírus das hepatites C e G (HGV/GBV-C)
• Beneficiário: Giovana Lótici Baggio
• Modalidade de apoio: Bolsas no Brasil - Doutorado