Herpes viruses in periodontal compromised sites: comparison between HIV-positive and -negative patients

Autor(es)

Grande, Sabrina Rosa ^{[1, 2]} ; Imbronito, Ana Vitoria ^[2] ; Okuda, Osmar Shizuo ^[2] ; Moreira Lotufo, Roberto Fraga ^[2] ; Gallottini Magalhaes, Marina Helena ^[1] ; Nunes, Fabio Daumas ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Oral Pathol, Sch Dent, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Dept Periodontol, Sch Dent, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF CLINICAL PERIODONTOLOGY; v. 35, n. 10, p. 838-845, OCT 2008.
• Citações Web of Science: 19

Resumo

Aims: The objective of this study was to compare the frequency of herpes simplex virus type 1 (HSV-1), Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) in subgingival plaque, saliva and peripheral blood of HIV-positive and-negative patients with periodontal disease. Materials and Methods: Fifty HIV-positive subjects (23 with gingivitis, 27 with periodontitis) and 50 healthy HIV-negative patients with chronic periodontitis were included in the study. Parameters of probing depth (PD), clinical attachment level (CAL), gingival index and plaque index were recorded. The samples were processed for viral identification by the nested polymerase chain reaction technique. Results: HCMV was the most prevalent virus in HIV-positive (82%) and-negative patients (84%), and the detection in the three samples was similar (p > 0.05). HSV-1 was the least prevalent virus in both groups, being detected in similar frequencies in oral sites and in peripheral blood. EBV-1 was found more frequently in saliva and subgingival plaque of HIV-positive patients than in HIV-negative patients (p <= 0.05). Conclusions: EBV-1 was more frequently recovered in oral sites of HIV-positive patients than in HIV-negative patients. (AU)

• Processo FAPESP: 04/07147-8 - Associação entre herpes simples vírus, citomegalovírus e Epstein-Barr vírus e peridodontite agressiva
• Beneficiário: Fabio Daumas Nunes
• Modalidade de apoio: Auxílio à Pesquisa - Regular