| Texto completo | |
| Autor(es): |
Tomita, Luciana Yuki
[1]
;
Longatto Filho, Adhemar
[2, 3]
;
Costa, Maria Cecilia
[4]
;
Avilla Andreoli, Maria Antonieta
[4]
;
Villa, Luisa Lina
[4]
;
Franco, Eduardo Luiz
[5]
;
Cardoso, Marly Augusto
[1]
;
Can, Brazilian Invest Nutr Cervical
Número total de Autores: 8
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, BR-01246904 Sao Paulo - Brazil
[2] Adolfo Lutz Inst, Dept Pathol, Sao Paulo - Brazil
[3] Univ Minho, Sch Hlth Sci, Res Inst, Braga - Portugal
[4] Ludwig Inst Canc Res, Sao Paulo - Brazil
[5] McGill Univ, Div Canc Epidemiol, Montreal, PQ - Canada
Número total de Afiliações: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | International Journal of Cancer; v. 126, n. 3, p. 703-714, FEB 1 2010. |
| Citações Web of Science: | 32 |
| Resumo | |
Cervical cancer is a leading cancer among women in developing countries. Infection with oncogenic human papillomavirus (HPV) types has been recognized as a necessary cause of this disease. Serum carotenoids and tocopherols have also been associated with risk for cervical neoplasia, but results from previous studies were not consistent. We evaluated the association of serum total carotene and tocopherols, and dietary intakes with the risk of newly diagnosed, histologically confirmed cervical intraepithelial neoplasia (CIN) grades 1, 2, 3 and invasive cancer in a hospital-based case-control study in Sao Paulo, Brazil. The investigation included 453 controls and 4 groups of cases (CIN1, n = 140; CIN2, n = 126; CIN3, n = 231; invasive cancer, n = 108) recruited from two major public clinics between 2003 and 2005. Increasing concentrations of serum lycopene were negatively associated with CIN1, CIN3 and cancer, with odds ratios (OR) (95% CI) for the highest compared to the lowest tertile of 0.53 (0.27-1.00, p for trend = 0.05), 0.48 (0.22-1.04, p for trend = 0.05) and 0.18 (0.06-0.52, p for trend = 0.002), respectively, after adjusting for confounding variables and HPV status. Increasing concentrations of serum alpha- and gamma-tocopherols, and higher dietary intakes of dark green and deep yellow vegetables/fruit were associated with nearly 50% decreased risk of CIN3. These results support the evidence that a healthy and balanced diet leading to provide high serum levels of antioxidants may reduce cervical neoplasia risk in low-income women. (AU) | |
| Processo FAPESP: | 02/11184-0 - Consumo alimentar e níveis séricos de micronutrientes: associação com lesões neoplásicas do colo uterino |
| Beneficiário: | Luciana Yuki Tomita |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |
| Processo FAPESP: | 03/03013-4 - Consumo alimentar e níveis séricos de micronutrientes: associação com lesões neoplásicas do colo uterino |
| Beneficiário: | Marly Augusto Cardoso |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |