| Texto completo | |
| Autor(es): |
Salomao, Emilianne M.
;
Toneto, Aline T.
;
Silva, Gisele O.
;
Gomes-Marcondes, Maria Cristina C.
[1]
Número total de Autores: 4
|
| Afiliação do(s) autor(es): | [1] State Univ Campinas UNICAMP, Inst Biol, Dept Anat Cell Biol & Physiol & Biophys, Lab Nutr & Canc, BR-13083970 Campinas, SP - Brazil
Número total de Afiliações: 1
|
| Tipo de documento: | Artigo Científico |
| Fonte: | NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL; v. 62, n. 8, p. 1095-1104, 2010. |
| Citações Web of Science: | 22 |
| Resumo | |
Leucine-supplemented diet can recover lean body mass and preserve muscle protein mass. Additionally, physical exercise can be an excellent alternative to improve the rehabilitation of cancer patients. Knowing these facts, we examined the effects of a leucine-rich diet with or without physical aerobic exercise on muscle protein metabolism in Walker tumor-bearing rats. Young rats were divided into 4 groups that did or did not perform light aerobic exercise (swim training) and were on a leucine-rich diet or a control diet for 2 mo. After this time, these animals were implanted or not with tumors (subcutaneously) following groups for either control diet or leucine-rich diet fed rats: control, trained, tumor-bearing, and trained tumor-bearing. Twenty-one days after implantation, the tumor growth induced a decrease in the muscle protein synthesis and increased the catabolic process, which was associated with an increase in the expression of the ubiquitin-proteasome subunits (20S, 19S, and 11S). In contrast, the exercise program minimized the muscle degradation process and increased muscle myosin content. Additionally, leucine supplementation also modulated proteasome subunits, especially the 19S and 11S. In summary, the exercise has beneficial effects by reducing tumor growth, leading to an improvement in protein turnover especially when in conjunction with a leucine-rich diet. (AU) | |
| Processo FAPESP: | 06/04645-2 - Estudo do metabolismo protéico em ratos implantados com carcinossarcoma de Walker 256, submetidos a atividade física associada a suplementação nutricional de leucina |
| Beneficiário: | Maria Cristina Cintra Gomes Marcondes |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 06/00974-1 - Atividade física associada ao crescimento tumoral e suplementação nutricional de leucina: estudo do metabolismo muscular, hepático e tumoral de proteína e carboidratos em ratos implantados com carcinos. |
| Beneficiário: | Emilianne Miguel Salomão |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |