Chemopreventive effects of Paullinia cupana Mart var. sorbilis, the guaraná, on mouse hepatocarcinogenesis

Autor(es)

Fukumasu, Heidge ^[1] ; Silva, Tereza Cristina da ; Avanzo, José Luis ; Lima, Cyntia Esteves de ; Mackowiak, Ivone Isabel ; Atroch, André ; Spinosa, Helenice de Souza ; Moreno, Fernando Salvador ; Dagli, Maria Lucia Zaidan

Afiliação do(s) autor(es)

^[1] Universidade de São Paulo (USP). Faculdade de Medicina Veterinária e Zootecnia. Departamento de Patologia - Brasil

• Tipo de documento: Artigo Científico
• Fonte: Cancer Letters; v. 233, n. 1, p. 158-164, Feb. 2006.
• Área do conhecimento: Ciências Agrárias - Medicina Veterinária
• Assunto(s): Antígenos Quimioprevenção Guaraná Paullinia cupana

Resumo

Guaraná (Paullinia cupana) is originally from Amazon, Brazil. Its effects on mouse hepatocarcinogenesis have been investigated in this study. Mice were treated with N-nitrosodiethylamine (DEN), received three different doses of P. cupana added to commercial food, and euthanized after 25 weeks. Gross lesions were quantified, and preneoplastic lesions (PNL) were histologically measured. Cellular proliferation was evaluated by immunobloting for the proliferating cell nuclear antigen (PCNA). The incidence and multiplicity of macroscopic lesions were reduced. The PNL number and PCNA expression were reduced in the highest P. cupana dose. According to these results, guaraná presented inhibitory effects on DEN hepatocarcinogenesis in mice. (AU)

• Processo FAPESP: 02/02736-0 - Avaliação dos efeitos quimiopreventivos e antineoplásicos do guaraná, Paullinia cupana
• Beneficiário: Heidge Fukumasu
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica